Tapered fibertrodes for optoelectrical neural interfacing in small brain volumes with reduced artefacts.
Journal
Nature materials
ISSN: 1476-4660
Titre abrégé: Nat Mater
Pays: England
ID NLM: 101155473
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
23
05
2020
accepted:
27
04
2022
pubmed:
7
6
2022
medline:
2
7
2022
entrez:
6
6
2022
Statut:
ppublish
Résumé
Deciphering the neural patterns underlying brain functions is essential to understanding how neurons are organized into networks. This deciphering has been greatly facilitated by optogenetics and its combination with optoelectronic devices to control neural activity with millisecond temporal resolution and cell type specificity. However, targeting small brain volumes causes photoelectric artefacts, in particular when light emission and recording sites are close to each other. We take advantage of the photonic properties of tapered fibres to develop integrated 'fibertrodes' able to optically activate small brain volumes with abated photoelectric noise. Electrodes are positioned very close to light emitting points by non-planar microfabrication, with angled light emission allowing the simultaneous optogenetic manipulation and electrical read-out of one to three neurons, with no photoelectric artefacts, in vivo. The unconventional implementation of two-photon polymerization on the curved taper edge enables the fabrication of recoding sites all around the implant, making fibertrodes a promising complement to planar microimplants.
Identifiants
pubmed: 35668147
doi: 10.1038/s41563-022-01272-8
pii: 10.1038/s41563-022-01272-8
pmc: PMC7612923
mid: EMS144588
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
826-835Subventions
Organisme : European Research Council
ID : 677683
Pays : International
Organisme : European Research Council
ID : 966674
Pays : International
Organisme : European Research Council
ID : 692943
Pays : International
Organisme : NINDS NIH HHS
ID : U01 NS094190
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NINDS NIH HHS
ID : UF1 NS108177
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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