Interleukin 15 modulates the effects of poly I:C maternal immune activation on offspring behaviour.
Age
Anxiety
Autism spectrum disorder
Interleukin 15
Maternal immune activation
Poly I:C
Pregnancy
Schizophrenia
Social behaviour
Startle
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
13
05
2022
accepted:
14
05
2022
entrez:
7
6
2022
pubmed:
8
6
2022
medline:
8
6
2022
Statut:
epublish
Résumé
Maternal infections during pregnancy are linked with an increased risk for disorders like Autism Spectrum Disorder and schizophrenia in the offspring. Although precise mechanisms are still unclear, clinical and preclinical evidence suggest a strong role for maternal immune activation (MIA) in the neurodevelopmental disruptions caused by maternal infection. Previously, studies using the Polyinosinic:Polycytidylic (Poly I:C) MIA preclinical model showed that cytokines like Interleukin 6 (Il6) are important mediators of MIA's effects. In this study, we hypothesized that Il15 may similarly act as a mediator of Poly I:C MIA, given its role in the antiviral immune response. To test this hypothesis, we induced Poly I:C MIA at gestational day 9.5 in wildtype (
Identifiants
pubmed: 35668725
doi: 10.1016/j.bbih.2022.100473
pii: S2666-3546(22)00063-1
pmc: PMC9166394
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100473Informations de copyright
© 2022 The Authors.
Références
Behav Pharmacol. 2018 Apr;29(2 and 3-Spec Issue):181-198
pubmed: 29462110
Biol Reprod. 1977 Sep;17(2):298-303
pubmed: 889997
J Neurosci. 2006 May 3;26(18):4752-62
pubmed: 16672647
Pediatr Res. 2013 Oct;74(4):393-401
pubmed: 23877071
Genes Brain Behav. 2004 Oct;3(5):287-302
pubmed: 15344922
J Biol Chem. 1997 Nov 14;272(46):28853-60
pubmed: 9360952
J Comp Neurol. 1992 Nov 22;325(4):473-92
pubmed: 1281843
J Reprod Fertil. 1981 Sep;63(1):215-20
pubmed: 7277322
Schizophr Bull. 2016 Jan;42(1):125-33
pubmed: 26303935
J Immunol. 2001 Aug 1;167(3):1179-87
pubmed: 11466332
Front Behav Neurosci. 2016 Jun 28;10:134
pubmed: 27445729
Dev Neurobiol. 2012 Oct;72(10):1317-26
pubmed: 22753006
Biol Psychiatry. 2007 Mar 1;61(5):688-93
pubmed: 16920078
Biol Psychiatry. 2017 Feb 1;81(3):265-276
pubmed: 27769567
J Neurosci. 2018 Mar 28;38(13):3358-3372
pubmed: 29491010
J Vis Exp. 2011 Sep 01;(55):e3446
pubmed: 21912367
Neurosci Biobehav Rev. 2005;29(6):913-47
pubmed: 15964075
J Neurosci. 2013 May 1;33(18):7654-66
pubmed: 23637159
PLoS One. 2020 Aug 6;15(8):e0231609
pubmed: 32760152
Psychol Med. 2014 Nov;44(15):3249-61
pubmed: 25065485
Paediatr Perinat Epidemiol. 2015 Jul;29(4):307-16
pubmed: 25989831
Prog Neurobiol. 1999 Oct;59(2):107-28
pubmed: 10463792
Brain Behav Immun Health. 2020 Oct 08;9:100156
pubmed: 34589898
Nat Rev Neurol. 2021 Sep;17(9):564-579
pubmed: 34341569
Brain Behav Immun. 2016 Nov;58:165-172
pubmed: 27287966
Mol Psychiatry. 2014 Feb;19(2):259-64
pubmed: 23337946
Wiley Interdiscip Rev Cogn Sci. 2016 Nov;7(6):406-421
pubmed: 27582415
Schizophr Res. 2010 Aug;121(1-3):46-54
pubmed: 20553865
J Neuroinflammation. 2012 Apr 30;9:83
pubmed: 22546005
World J Biol Psychiatry. 2013 Sep;14(7):528-38
pubmed: 22175527
J Neurosci. 2007 Oct 3;27(40):10695-702
pubmed: 17913903
Brain Res. 2017 Jan 1;1654(Pt B):123-144
pubmed: 27590721
Neurosci Biobehav Rev. 2020 Jun;113:546-567
pubmed: 32320814
Acta Microbiol Immunol Hung. 2013 Sep;60(3):271-88
pubmed: 24060552
Immunity. 1998 Nov;9(5):669-76
pubmed: 9846488
J Neurosci. 2003 Jan 1;23(1):297-302
pubmed: 12514227
PLoS One. 2009 Jul 24;4(7):e6354
pubmed: 19629183
J Mol Neurosci. 2010 Jun;41(2):315-21
pubmed: 20012227
Nature. 2017 Sep 28;549(7673):528-532
pubmed: 28902840
Microbes Infect. 2012 Mar;14(3):247-61
pubmed: 22064066
Nature. 2017 Sep 28;549(7673):482-487
pubmed: 28902835
Mol Psychiatry. 2017 Feb;22(2):273-279
pubmed: 27217154
Ann Neurol. 2013 Jul;74(1):11-9
pubmed: 23907982
Am J Psychiatry. 2004 May;161(5):889-95
pubmed: 15121655
Neurosci Res. 2009 Jul;64(3):297-305
pubmed: 19447299
Schizophr Bull. 2000;26(2):287-95
pubmed: 10885631
Paediatr Perinat Epidemiol. 2012 Jul;26(4):373-85
pubmed: 22686389
Am J Psychiatry. 2009 Sep;166(9):1025-30
pubmed: 19487391
J Neuroimmunol. 2018 Oct 15;323:87-93
pubmed: 30196839
Brain Pathol. 2007 Oct;17(4):448-59
pubmed: 17919130
Glia. 2008 Apr;56(5):494-505
pubmed: 18240307
Neuroscience. 2014 Sep 26;277:294-305
pubmed: 24969132
Annu Rev Immunol. 2006;24:657-79
pubmed: 16551262
J Neurosci. 2018 Oct 3;38(40):8588-8604
pubmed: 30126973
J Neurol Sci. 1998 Mar 5;155(2):170-7
pubmed: 9562262
Mol Psychiatry. 2017 Jan;22(1):102-112
pubmed: 27021823
Transl Psychiatry. 2013 Mar 12;3:e240
pubmed: 23481627
J Neurosci. 1994 Mar;14(3 Pt 1):1176-94
pubmed: 8120618
Autism Res. 2020 Oct;13(10):1698-1717
pubmed: 32918359
J Exp Med. 2000 Mar 6;191(5):771-80
pubmed: 10704459
Brain Res. 2017 Jan 1;1654(Pt B):87-94
pubmed: 27060769
Arch Gen Psychiatry. 2004 Aug;61(8):774-80
pubmed: 15289276
J Neuroinflammation. 2014 Jun 20;11:113
pubmed: 24951035
Biol Reprod. 2017 Jan 1;96(1):145-158
pubmed: 28395334
Mol Psychiatry. 2008 Feb;13(2):208-21
pubmed: 17579604
Dev Dyn. 2018 Apr;247(4):588-619
pubmed: 29226543
Mol Psychiatry. 2018 Mar;23(3):759-766
pubmed: 28607458
J Neurosci. 2010 Mar 31;30(13):4725-34
pubmed: 20357123
Nat Rev Immunol. 2011 Sep 23;11(10):658-71
pubmed: 21941294
Hematol Oncol Stem Cell Ther. 2015 Jun;8(2):47-55
pubmed: 25571788
Schizophr Bull. 2017 Jan;43(1):171-179
pubmed: 27343007
Birth Defects Res B Dev Reprod Toxicol. 2003 Aug;68(4):321-34
pubmed: 14666995
Brain Behav Immun. 2010 Nov;24(8):1340-6
pubmed: 20600810
Brain Behav Immun. 2019 Jan;75:48-59
pubmed: 30218784
Schizophr Bull. 2009 May;35(3):631-7
pubmed: 18832344
Psychol Med. 2013 Feb;43(2):239-57
pubmed: 22717193
J Immunol. 1997 Sep 15;159(6):2941-51
pubmed: 9300718
J Immunol. 2018 Aug 1;201(3):845-850
pubmed: 29967099
Cent Eur J Immunol. 2019;44(4):337-356
pubmed: 32140045
Prog Neuropsychopharmacol Biol Psychiatry. 2015 Dec 3;63:63-9
pubmed: 26051209
Brain Behav Immun. 2008 May;22(4):469-86
pubmed: 18023140
Brain Behav Immun. 2013 May;30:168-75
pubmed: 23402795
Paediatr Perinat Epidemiol. 2016 Mar;30(2):181-9
pubmed: 26860445
Psychoneuroendocrinology. 2011 Feb;36(2):266-78
pubmed: 20724079
Prog Neurobiol. 2020 Feb;185:101734
pubmed: 31863802
Brain Behav Immun. 2016 Jul;55:25-38
pubmed: 26408796
Mol Biol Cell. 2011 Jun 15;22(12):1960-70
pubmed: 21508317
Schizophr Res. 2016 Apr;172(1-3):41-5
pubmed: 26897476
Neuroreport. 1996 Apr 10;7(5):1062-6
pubmed: 8804052
Nat Immunol. 2003 May;4(5):491-6
pubmed: 12692549
J Autism Dev Disord. 2010 Dec;40(12):1423-30
pubmed: 20414802