Zfp281 Inhibits the Pluripotent-to-Totipotent State Transition in Mouse Embryonic Stem Cells.
2C-like cells
Tet1
Zfp281
pluripotency
primed-state pluripotency
totipotency
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
02
2022
accepted:
19
04
2022
entrez:
7
6
2022
pubmed:
8
6
2022
medline:
8
6
2022
Statut:
epublish
Résumé
The cell-fate transition between pluripotent and totipotent states determines embryonic development and the first cell-lineage segregation. However, limited by the scarcity of totipotent embryos, regulators on this transition remain largely elusive. A novel model to study the transition has been recently established, named the 2-cell-like (2C-like) model. The 2C-like cells are rare totipotent-like cells in the mouse embryonic stem cell (mESC) culture. Pluripotent mESCs can spontaneously transit into and out of the 2C-like state. We previously dissected the transcriptional roadmap of the transition. In this study, we revealed that Zfp281 is a novel regulator for the pluripotent-to-totipotent transition in mESCs. Zfp281 is a transcriptional factor involved in the cell-fate transition. Our study shows that Zfp281 represses transcripts upregulated during the 2C-like transition
Identifiants
pubmed: 35669510
doi: 10.3389/fcell.2022.879428
pii: 879428
pmc: PMC9163740
doi:
Types de publication
Journal Article
Langues
eng
Pagination
879428Informations de copyright
Copyright © 2022 Wen, Lin, Wu, Cao and Fu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cell. 2018 Jul 12;174(2):391-405.e19
pubmed: 29937225
Development. 2014 Feb;141(3):526-37
pubmed: 24423662
Cell. 2015 May 21;161(5):1202-1214
pubmed: 26000488
Nat Cell Biol. 2020 Feb;22(2):175-186
pubmed: 31932739
Dev Cell. 2014 Apr 14;29(1):7-19
pubmed: 24735877
BMC Genomics. 2014 Jul 11;15:583
pubmed: 25012247
Bioinformatics. 2014 Feb 15;30(4):523-30
pubmed: 24336805
Stem Cells. 2008 Nov;26(11):2791-9
pubmed: 18757296
FEBS J. 2010 Jan;277(1):210-23
pubmed: 19951360
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Natl Sci Rev. 2015 Jun;2(2):217-225
pubmed: 26114010
Cell Rep. 2019 May 7;27(6):1742-1754.e6
pubmed: 31067460
Curr Opin Genet Dev. 2020 Oct;64:26-30
pubmed: 32599301
EMBO Rep. 2019 May;20(5):
pubmed: 30948459
Mol Cell Biol. 2019 Nov 25;39(24):
pubmed: 31570506
Nat Cell Biol. 2018 Apr;20(4):382-392
pubmed: 29593328
Nat Methods. 2020 Oct;17(10):991-1001
pubmed: 32868927
Nat Commun. 2021 Aug 11;12(1):4856
pubmed: 34381034
Protein Cell. 2021 Jun;12(6):455-474
pubmed: 33886094
Nucleic Acids Res. 2012 May;40(10):4288-97
pubmed: 22287627
Nature. 2011 May 19;473(7347):389-93
pubmed: 21451524
Nature. 2012 Jul 5;487(7405):57-63
pubmed: 22722858
Genes Dev. 2014 Oct 1;28(19):2103-19
pubmed: 25223896
Nature. 2021 Mar;591(7849):322-326
pubmed: 33658714
Nat Cell Biol. 2019 Jul;21(7):835-844
pubmed: 31209294
Cell Stem Cell. 2020 Feb 6;26(2):234-250.e7
pubmed: 32032525
Cell Rep. 2020 Jan 7;30(1):25-36.e6
pubmed: 31914391
Curr Opin Genet Dev. 2020 Oct;64:13-20
pubmed: 32563750
Nat Genet. 2017 Jun;49(6):941-945
pubmed: 28459456
Genes Dev. 2019 Feb 1;33(3-4):194-208
pubmed: 30692203
Cell Prolif. 2021 Jun;54(6):e13049
pubmed: 33960560
PLoS Biol. 2019 Jun 21;17(6):e3000324
pubmed: 31226106
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Stem Cell Reports. 2021 Nov 9;16(11):2659-2673
pubmed: 34624246
Cell Stem Cell. 2016 Sep 1;19(3):355-69
pubmed: 27345836
Cell Res. 2019 Nov;29(11):956-959
pubmed: 31591446
Protein Cell. 2021 Mar;12(3):213-219
pubmed: 32812113
Nat Genet. 2017 Jun;49(6):935-940
pubmed: 28459454
Nat Genet. 2017 Jun;49(6):925-934
pubmed: 28459457
Nat Struct Mol Biol. 2015 Sep;22(9):662-71
pubmed: 26237512
Biochem Biophys Res Commun. 2020 Feb 5;522(2):422-427
pubmed: 31767152
Nucleic Acids Res. 2017 Dec 1;45(21):12301-12310
pubmed: 29036642
Sci Adv. 2020 May 29;6(22):eaay5181
pubmed: 32523982
Genes Dev. 2014 May 15;28(10):1042-7
pubmed: 24831699
Nucleic Acids Res. 2021 Mar 18;49(5):2569-2582
pubmed: 33621320
Nucleic Acids Res. 2021 Dec 2;49(21):12167-12177
pubmed: 34791385