Cognitive enhancement: Effects of methylphenidate, modafinil, and caffeine on latent memory and resting state functional connectivity in healthy adults.
Adult
Brain
/ diagnostic imaging
Brain Mapping
/ methods
Caffeine
/ pharmacology
Central Nervous System Stimulants
/ pharmacology
Cognition
Double-Blind Method
Humans
Magnetic Resonance Imaging
/ methods
Male
Methylphenidate
/ pharmacology
Modafinil
/ pharmacology
Neural Pathways
/ diagnostic imaging
caffeine
memory
methylphenidate
modafinil
neuroenhancement
neuroimaging
resting state functional connectivity
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 10 2022
01 10 2022
Historique:
revised:
15
04
2022
received:
29
10
2021
accepted:
20
04
2022
pubmed:
8
6
2022
medline:
9
9
2022
entrez:
7
6
2022
Statut:
ppublish
Résumé
Stimulants like methylphenidate, modafinil, and caffeine have repeatedly shown to enhance cognitive processes such as attention and memory. However, brain-functional mechanisms underlying such cognitive enhancing effects of stimulants are still poorly characterized. Here, we utilized behavioral and resting-state fMRI data from a double-blind randomized placebocontrolled study of methylphenidate, modafinil, and caffeine in 48 healthy male adults. The results show that performance in different memory tasks is enhanced, and functional connectivity (FC) specifically between the frontoparietal network (FPN) and default mode network (DMN) is modulated by the stimulants in comparison to placebo. Decreased negative connectivity between right prefrontal and medial parietal but also between medial temporal lobe and visual brain regions predicted stimulant-induced latent memory enhancement. We discuss dopamine's role in attention and memory as well as its ability to modulate FC between large-scale neural networks (e.g., FPN and DMN) as a potential cognitive enhancement mechanism.
Identifiants
pubmed: 35670369
doi: 10.1002/hbm.25949
pmc: PMC9435011
doi:
Substances chimiques
Central Nervous System Stimulants
0
Methylphenidate
207ZZ9QZ49
Caffeine
3G6A5W338E
Modafinil
R3UK8X3U3D
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4225-4238Informations de copyright
© 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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