All Glioblastoma Are Not Equal: Distinct Spatial Immune Profiles Between De Novo and Recurrent Tumors.


Journal

Cancer immunology research
ISSN: 2326-6074
Titre abrégé: Cancer Immunol Res
Pays: United States
ID NLM: 101614637

Informations de publication

Date de publication:
01 07 2022
Historique:
received: 18 05 2022
accepted: 18 05 2022
pubmed: 8 6 2022
medline: 6 7 2022
entrez: 7 6 2022
Statut: ppublish

Résumé

Lack of insight into the immunosuppressive microenvironment of glioblastoma (GBM) hinders successful application of immunotherapy. In this issue, Alanio and colleagues identify a distinct T-cell localization profile between recurrent and de novo GBM highlighting the importance of spatial heterogeneity and providing new avenues to explore to improve GBM outcome. See related article by Alanio et al., p. 800 (3).

Identifiants

pubmed: 35670711
pii: 699400
doi: 10.1158/2326-6066.CIR-22-0400
doi:

Types de publication

Editorial Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

787

Subventions

Organisme : NCI NIH HHS
ID : K99 CA248611
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS127083
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA245705
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentOn

Informations de copyright

©2022 American Association for Cancer Research.

Auteurs

Defne Bayik (D)

Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.

Juyeun Lee (J)

Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

Justin D Lathia (JD)

Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.

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Classifications MeSH