New glycoconjugation strategies for Ruthenium(II) arene complexes via phosphane ligands and assessment of their antiproliferative activity.
Anticancer metal complexes
Apoptosis
Carbohydrate complexes
Cell-cycle
Cytotoxicity
Glycoconjugation
Mitochondrial membrane potential
Phosphane ligand
Ruthenium(II) arene
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
23
02
2022
revised:
17
05
2022
accepted:
20
05
2022
pubmed:
8
6
2022
medline:
22
6
2022
entrez:
7
6
2022
Statut:
ppublish
Résumé
Glycoconjugation is a powerful tool to improve the anticancer activity of metal complexes. Herein, we modified commercial arylphosphanes with carbohydrate-derived fragments for the preparation of novel glycoconjugated ruthenium(II) p-cymene complexes. Specifically, d-galactal and d-allal-derived vinyl epoxides (VEβ and VEα) were coupled with (2-hydroxyphenyl)diphenylphosphane, affording the 2,3-unsaturated glycophosphanes 1β and 1α. Ligand exchange with [Ru(C
Identifiants
pubmed: 35671646
pii: S0045-2068(22)00306-6
doi: 10.1016/j.bioorg.2022.105901
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Coordination Complexes
0
Ligands
0
Phosphines
0
Ruthenium
7UI0TKC3U5
phosphine
FW6947296I
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105901Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.