Virucidal activities of novel hand hygiene and surface disinfectant formulations containing EGCG-palmitates (EC16).
Alcohol-resistant microorganisms
Green tea polyphenols
Non-toxic formulations
Norovirus
Novel antiseptics
Journal
American journal of infection control
ISSN: 1527-3296
Titre abrégé: Am J Infect Control
Pays: United States
ID NLM: 8004854
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
19
02
2022
revised:
30
05
2022
accepted:
31
05
2022
medline:
23
10
2023
pubmed:
8
6
2022
entrez:
7
6
2022
Statut:
ppublish
Résumé
Non-toxic hand hygiene and surface disinfectant products with virucidal activity against alcohol-resistant nonenveloped norovirus are in urgent need. Alcohol-based formulations were made with epigallocatechin-3-gallate-palmitate (EC16), an FDA accepted food additive. Based on in-house testing of formulations, 3 prototypes, PTV80 hand gel, PST70 surface disinfectant spray and PST70 surface disinfectant wipe, were selected from in-house tests for independent testing at GLP (good laboratory practice) laboratories according to EN 14476:2019 (hand gel), ASTM test method E1053-20 (spray), and ASTM E2362-15, E1053, and ASTM E2896-12 (wipe). The PTV80 hand gel prototype demonstrated a >99.999% reduction of murine norovirus S99 infectivity in 60 seconds. Carrier testing of the PST70 surface spray and surface wipe demonstrated reduction of feline calicivirus infectivity by >99.99% in 60 seconds. In addition, testing with human coronavirus and human herpes simplex virus demonstrated >99.99% efficacy in 60 seconds, consistent with broad spectrum virucidal activity. The novel non-toxic prototypes containing EC16 were found to be suitable for use in future hand sanitizer gel, surface disinfectant spray and wipe products against norovirus. Products based on these formulations could be used safely to help prevent and control norovirus and other emerging virus outbreaks, pending future studies.
Sections du résumé
BACKGROUND
Non-toxic hand hygiene and surface disinfectant products with virucidal activity against alcohol-resistant nonenveloped norovirus are in urgent need.
METHOD
Alcohol-based formulations were made with epigallocatechin-3-gallate-palmitate (EC16), an FDA accepted food additive. Based on in-house testing of formulations, 3 prototypes, PTV80 hand gel, PST70 surface disinfectant spray and PST70 surface disinfectant wipe, were selected from in-house tests for independent testing at GLP (good laboratory practice) laboratories according to EN 14476:2019 (hand gel), ASTM test method E1053-20 (spray), and ASTM E2362-15, E1053, and ASTM E2896-12 (wipe).
RESULTS
The PTV80 hand gel prototype demonstrated a >99.999% reduction of murine norovirus S99 infectivity in 60 seconds. Carrier testing of the PST70 surface spray and surface wipe demonstrated reduction of feline calicivirus infectivity by >99.99% in 60 seconds. In addition, testing with human coronavirus and human herpes simplex virus demonstrated >99.99% efficacy in 60 seconds, consistent with broad spectrum virucidal activity.
CONCLUSIONS
The novel non-toxic prototypes containing EC16 were found to be suitable for use in future hand sanitizer gel, surface disinfectant spray and wipe products against norovirus. Products based on these formulations could be used safely to help prevent and control norovirus and other emerging virus outbreaks, pending future studies.
Identifiants
pubmed: 35671844
pii: S0196-6553(22)00469-2
doi: 10.1016/j.ajic.2022.05.027
pmc: PMC9912545
mid: NIHMS1813826
pii:
doi:
Substances chimiques
Disinfectants
0
epigallocatechin gallate
BQM438CTEL
Catechin
8R1V1STN48
Ethanol
3K9958V90M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1212-1219Subventions
Organisme : NIAID NIH HHS
ID : R41 AI124738
Pays : United States
Organisme : NIAID NIH HHS
ID : R42 AI124738
Pays : United States
Informations de copyright
Copyright © 2022 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
Références
Infect Dis Ther. 2018 Jun;7(2):235-247
pubmed: 29761329
Appl Environ Microbiol. 2010 Jan;76(2):394-9
pubmed: 19933337
Infect Control Hosp Epidemiol. 2011 Oct;32(10):939-69
pubmed: 21931246
Fed Regist. 2017 Dec 20;82(242):60474-503
pubmed: 29260839
Microbiol Infect Dis. 2021;5(6):
pubmed: 35350749
Antimicrob Agents Chemother. 2008 Mar;52(3):962-70
pubmed: 18195068
Food Chem Toxicol. 2013 Feb;52:207-15
pubmed: 23182741
J Hosp Infect. 2015 Jul;90(3):226-34
pubmed: 25936671
J Food Prot. 2016 Jul;79(7):1273-94
pubmed: 27357051
J Food Prot. 2010 Dec;73(12):2232-8
pubmed: 21219741
J Hosp Infect. 2015 Dec;91(4):371-2
pubmed: 26518271
Food Environ Virol. 2016 Mar;8(1):1-12
pubmed: 26445948
Am J Infect Control. 2011 May;39(4):296-301
pubmed: 21411187
Microbiol Infect Dis. 2021;5(5):
pubmed: 35368369
Sci Rep. 2020 Sep 28;10(1):15878
pubmed: 32985508
Microbiol Infect Dis. 2021;5(2):
pubmed: 35291211