The role of the immune system in the pathogenesis of NAFLD and potential therapeutic impacts of mesenchymal stem cell-derived extracellular vesicles.
Exosomes
Extracellular vesicle
Immune response
Inflammation
Liver disease
Mesenchymal stem cells
NAFLD
miRNA
Journal
Stem cell research & therapy
ISSN: 1757-6512
Titre abrégé: Stem Cell Res Ther
Pays: England
ID NLM: 101527581
Informations de publication
Date de publication:
07 06 2022
07 06 2022
Historique:
received:
21
11
2021
accepted:
23
05
2022
entrez:
7
6
2022
pubmed:
8
6
2022
medline:
10
6
2022
Statut:
epublish
Résumé
Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by intra-hepatocyte triglyceride accumulation and concomitant involvement of the immune system with subsequent histological changes, tissue damage, and clinical findings. There are various molecular pathways involved in the progression of NAFLD including lipotoxicity, endoplasmic reticulum stress, and the immune response. Both innate and adaptive immune systems are involved in the NAFLD pathogenesis, and crosstalk between the immune cells and liver cells participates in its initiation and progression. Among the various treatments for this disease, new cell based therapies have been proposed. Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSC) (MSC-EVs) are new cell-free vehicles with low immunogenicity, which can suppress detrimental immune responses in inflamed tissues. This review aimed to express the immune system's molecular pathways associated with the initiation and progression of NAFLD. Then, the possible role of MSC-EVs in the treatment of this entity through immune response modulation was discussed. Finally, engineered EVs enhanced by specific therapeutic miRNA were suggested for alleviating the pathological cellular events in liver disease.
Identifiants
pubmed: 35672797
doi: 10.1186/s13287-022-02929-6
pii: 10.1186/s13287-022-02929-6
pmc: PMC9175371
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
242Informations de copyright
© 2022. The Author(s).
Références
Diabetes. 2016 Oct;65(10):3185-99
pubmed: 27486236
Front Immunol. 2014 Nov 04;5:556
pubmed: 25414703
Mol Med. 2019 May 2;25(1):16
pubmed: 31046673
Clin Investig Arterioscler. 2019 May - Jun;31(3):111-118
pubmed: 30987865
Exp Mol Pathol. 2021 Feb;118:104566
pubmed: 33160961
Clin Exp Immunol. 2011 Nov;166(2):281-90
pubmed: 21985374
Lab Invest. 2013 Mar;93(3):311-21
pubmed: 23318884
J Gastroenterol Hepatol. 2007 Apr;22(4):491-7
pubmed: 17376039
Proteomics. 2013 May;13(10-11):1637-53
pubmed: 23335344
Stem Cell Res Ther. 2018 Jan 29;9(1):17
pubmed: 29378639
Am J Pathol. 2009 Oct;175(4):1473-82
pubmed: 19729473
Mol Cells. 2019 Dec 31;42(12):906-918
pubmed: 31826604
Crit Rev Clin Lab Sci. 2011 May-Jun;48(3):97-113
pubmed: 21875310
Hepatology. 2013 Aug;58(2):589-602
pubmed: 23322710
J Cell Physiol. 2018 Dec;233(12):9330-9344
pubmed: 29266258
Hepatology. 2009 Aug;50(2):612-21
pubmed: 19575456
Transplantation. 2019 Jan;103(1):e1-e13
pubmed: 30300287
Hepatology. 2011 Nov;54(5):1620-30
pubmed: 21809356
Cytotherapy. 2018 May;20(5):687-696
pubmed: 29622483
J Cell Biochem. 2018 Nov;119(11):9433-9443
pubmed: 30074271
Nature. 2008 Jul 24;454(7203):455-62
pubmed: 18650916
Nature. 1998 Mar 19;392(6673):245-52
pubmed: 9521319
Int Immunopharmacol. 2020 Jan;78:105985
pubmed: 31776092
Gastroenterology. 2011 Jan;140(1):124-31
pubmed: 20858492
World J Gastroenterol. 2010 Oct 7;16(37):4652-60
pubmed: 20872965
J Hepatol. 2015 Jun;62(6):1367-74
pubmed: 25666017
Hepatology. 2021 Aug;74(2):704-722
pubmed: 33609303
Antioxid Redox Signal. 2015 Dec 1;23(16):1255-69
pubmed: 26058518
Gastroenterology. 2012 Sep;143(3):765-776.e3
pubmed: 22687286
Stem Cells. 2018 Mar;36(3):434-445
pubmed: 29239062
Int J Stroke. 2018 Aug;13(6):612-632
pubmed: 29786478
J Cell Mol Med. 2010 Jun;14(6B):1726-39
pubmed: 19508382
Pancreas. 2017 Jul;46(6):782-788
pubmed: 28609367
J Lipid Res. 2013 May;54(5):1326-34
pubmed: 23417738
Hepatology. 2018 May;67(5):1754-1767
pubmed: 28833331
JCI Insight. 2019 Nov 1;4(21):
pubmed: 31581150
Biochem Biophys Res Commun. 2018 Sep 18;503(4):2611-2618
pubmed: 30126637
J Gastroenterol Hepatol. 2002 Dec;17 Suppl 3:S377-84
pubmed: 12472967
Scand J Gastroenterol. 2013 Mar;48(3):352-7
pubmed: 23268566
Science. 2011 Sep 30;333(6051):1891-4
pubmed: 21852455
J Hepatol. 2011 Nov;55(5):1086-94
pubmed: 21354232
Diabetes. 2016 Jul;65(7):1904-15
pubmed: 27207533
Gastroenterology. 2010 Jul;139(1):323-34.e7
pubmed: 20347818
Immunol Lett. 2012 Sep;147(1-2):47-54
pubmed: 22705267
Hepatology. 2010 Aug;52(2):774-88
pubmed: 20683968
Mol Ther. 2020 Feb 5;28(2):479-489
pubmed: 31757759
Nat Rev Gastroenterol Hepatol. 2010 Apr;7(4):195-203
pubmed: 20195271
Nat Cell Biol. 2011 Mar;13(3):184-90
pubmed: 21364565
Hepatology. 2010 Nov;52(5):1836-46
pubmed: 21038418
Adv Exp Med Biol. 2019;1201:175-193
pubmed: 31898787
J Biol Chem. 2013 Aug 30;288(35):25350-25361
pubmed: 23888053
Regen Ther. 2020 May 15;14:252-261
pubmed: 32455155
Hepatology. 2013 Feb;57(2):577-89
pubmed: 22987396
Stem Cell Res Ther. 2016 Sep 09;7(1):131
pubmed: 27612948
Sci Rep. 2017 Jun 28;7(1):4323
pubmed: 28659587
J Hepatol. 2018 Feb;68(2):238-250
pubmed: 29154966
Stem Cells Dev. 2019 Nov 1;28(21):1451-1462
pubmed: 31495270
Toxicol Pathol. 2005;33(1):52-62
pubmed: 15805056
J Biol Chem. 2012 Nov 23;287(48):40161-72
pubmed: 23066023
Cells. 2019 Jul 15;8(7):
pubmed: 31311206
Cell Biochem Biophys. 2015 Nov;73(2):479-487
pubmed: 27352342
Int J Mol Sci. 2018 Oct 10;19(10):
pubmed: 30309020
J Hepatol. 2011 Apr;54(4):795-809
pubmed: 21145844
J Immunol. 2016 Jan 1;196(1):97-105
pubmed: 26621860
Cell Metab. 2012 Oct 3;16(4):473-86
pubmed: 23040069
Liver Int. 2012 Mar;32(3):370-82
pubmed: 22097967
J Biol Chem. 2018 Mar 16;293(11):4110-4121
pubmed: 29386355
Stem Cell Res Ther. 2014 Mar 19;5(2):40
pubmed: 24646750
Minerva Endocrinol. 2017 Jun;42(2):92-108
pubmed: 27711029
Stem Cells. 2014 Jan;32(1):116-25
pubmed: 23939814
Stem Cells Transl Med. 2015 Oct;4(10):1131-43
pubmed: 26339036
Semin Liver Dis. 2017 Aug;37(3):189-197
pubmed: 28847030
J Toxicol Sci. 2014 Jun;39(3):413-23
pubmed: 24849676
Am J Pathol. 2010 Nov;177(5):2334-46
pubmed: 20847291
Cell Mol Immunol. 2007 Oct;4(5):321-8
pubmed: 17976311
Hepatology. 2014 Apr;59(4):1393-405
pubmed: 24254368
Nat Cell Biol. 2000 Jun;2(6):326-32
pubmed: 10854322
Hepatology. 2010 Jan;51(1):92-102
pubmed: 19998387
J Hepatol. 2017 Jun;66(6):1300-1312
pubmed: 28267621
Biochem Biophys Res Commun. 2019 Jan 15;508(3):735-741
pubmed: 30528233
Front Immunol. 2021 Feb 05;11:591065
pubmed: 33613514
Cardiovasc Res. 2019 Jun 1;115(7):1205-1216
pubmed: 30753344
Cell Transplant. 2013;22(2):369-79
pubmed: 23433427
Cytokine. 2016 Jun;82:102-11
pubmed: 26868085
EMBO J. 2011 Apr 6;30(7):1357-75
pubmed: 21407177
Eur J Gastroenterol Hepatol. 2009 Jun;21(6):673-80
pubmed: 19318971
Semin Liver Dis. 2007 May;27(2):173-93
pubmed: 17520517
Hepatology. 2012 Aug;56(2):747-59
pubmed: 22392635
Mol Immunol. 2018 Jan;93:38-46
pubmed: 29145157
Cell Transplant. 2015;24(12):2615-27
pubmed: 25695896
EBioMedicine. 2018 Oct;36:140-150
pubmed: 30197023
Cells. 2020 May 07;9(5):
pubmed: 32392899
J Neuroinflammation. 2019 Nov 13;16(1):216
pubmed: 31722731
Hepatology. 2013 Apr;57(4):1366-77
pubmed: 23152128
Mol Metab. 2018 Feb;8:117-131
pubmed: 29289645
Nat Med. 2015 Jul;21(7):677-87
pubmed: 26121197
J Hepatol. 2017 Jun;66(6):1241-1250
pubmed: 28108233
Sci Rep. 2015 Nov 25;5:17192
pubmed: 26603489
Diabetologia. 2014 Aug;57(8):1664-73
pubmed: 24838680
World J Stem Cells. 2010 Aug 26;2(4):67-80
pubmed: 21607123
J Surg Res. 2014 May 1;188(1):280-9
pubmed: 24560349
Cell Mol Immunol. 2021 Jan;18(1):45-56
pubmed: 33041338
Biomolecules. 2020 Oct 30;10(11):
pubmed: 33143043
J Hepatol. 2007 Oct;47(4):571-9
pubmed: 17644211
Clin Exp Pharmacol Physiol. 2016 Jan;43(1):13-21
pubmed: 26444279
J Gastroenterol Hepatol. 2013 Dec;28 Suppl 4:64-70
pubmed: 24251707
Liver Transpl. 2017 Jun;23(6):791-803
pubmed: 28407355
Hepatology. 2006 Feb;43(2 Suppl 1):S54-62
pubmed: 16447271
Stem Cells Transl Med. 2020 Jan;9(1):39-46
pubmed: 31411820
Hepatology. 2014 Jan;59(1):130-42
pubmed: 23832548
Nat Immunol. 2015 Apr;16(4):376-85
pubmed: 25729921
Cell Rep. 2017 Jul 5;20(1):124-135
pubmed: 28683306
J Hepatol. 2021 Aug;75(2):454-461
pubmed: 34019941
J Hematol Oncol. 2018 Dec 7;11(1):135
pubmed: 30526632
Cell Mol Immunol. 2017 Feb;14(2):143-145
pubmed: 28017959
Am J Transl Res. 2018 Apr 15;10(4):1053-1070
pubmed: 29736200
Life Sci. 2019 Sep 1;232:116632
pubmed: 31278944
Hepatology. 2011 Jan;53(1):106-15
pubmed: 20967826
J Clin Invest. 2009 Nov;119(11):3213-25
pubmed: 19855130
J Clin Invest. 2016 Mar 1;126(3):859-64
pubmed: 26808498
Nature. 2015 Feb 26;518(7540):547-51
pubmed: 25470051
Stem Cells Dev. 2016 Dec 15;25(24):1874-1883
pubmed: 27649744
Metabolism. 2014 Feb;63(2):283-95
pubmed: 24286856
Gastroenterology. 2012 Jun;142(7):1592-609
pubmed: 22656328
Metabolism. 2021 Jan;114:154342
pubmed: 32810487
Stem Cells Transl Med. 2017 Apr;6(4):1262-1272
pubmed: 28213967
EBioMedicine. 2016 Jun;8:72-82
pubmed: 27428420
Annu Rev Biomed Eng. 2010 Aug 15;12:87-117
pubmed: 20415588
World J Gastroenterol. 2011 Apr 7;17(13):1725-31
pubmed: 21483633
Gastroenterology. 2012 Oct;143(4):1061-72
pubmed: 22705178
Inflamm Regen. 2016 Nov 17;36:26
pubmed: 29259699
Lancet Diabetes Endocrinol. 2014 Nov;2(11):901-10
pubmed: 24731669
J Neurosurg. 2015 Apr;122(4):856-67
pubmed: 25594326
Nat Med. 2018 Jul;24(7):908-922
pubmed: 29967350
Am J Physiol Gastrointest Liver Physiol. 2010 Jan;298(1):G107-16
pubmed: 19875703
Oncotarget. 2016 Jun 7;7(23):33649-61
pubmed: 27172901
Biomed Res Int. 2017;2017:5356760
pubmed: 28589143
Stem Cells Int. 2018 Dec 24;2018:3212643
pubmed: 30675167
FASEB J. 2019 Feb;33(2):1695-1710
pubmed: 30226809
Obes Surg. 2007 Oct;17(10):1381-8
pubmed: 18000736
Am J Respir Crit Care Med. 2017 Nov 15;196(10):1275-1286
pubmed: 28598224
PLoS One. 2015 Oct 15;10(10):e0140551
pubmed: 26469068
Diabetologia. 2010 Aug;53(8):1795-806
pubmed: 20407745
Nat Rev Immunol. 2017 May;17(5):306-321
pubmed: 28317925
J Dig Dis. 2016 Jul;17(7):464-74
pubmed: 27216040
Can J Gastroenterol Hepatol. 2016;2016:6489012
pubmed: 27446858
Cold Spring Harb Perspect Biol. 2013 Mar 01;5(3):a013169
pubmed: 23388626