Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing.
biological motor
cochlea
electromotility
imaginary capacitance
piezoelectricity
prestin
Journal
Journal of the Royal Society, Interface
ISSN: 1742-5662
Titre abrégé: J R Soc Interface
Pays: England
ID NLM: 101217269
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
entrez:
8
6
2022
pubmed:
9
6
2022
medline:
10
6
2022
Statut:
ppublish
Résumé
Outer hair cells are the cellular motors in the mammalian inner ear responsible for sensitive high-frequency hearing. Motor function over the frequency range of human hearing requires expression of the protein prestin in the OHC lateral membrane, which imparts piezoelectric properties to the cell membrane. In the present report, electrical power consumption and mechanical power output of the OHC membrane-motor complex are determined using previously published voltage-clamp data from isolated OHCs and membrane patches. Results reveal that power output peaks at a best frequency much higher than implied by the low-pass character of nonlinear capacitance, and much higher than the whole-cell resistive-capacitive corner frequency. High frequency power output is enabled by a -90° shift in the phase of electrical charge displacement in the membrane, manifested electrically as emergence of imaginary-valued nonlinear capacitance.
Identifiants
pubmed: 35673856
doi: 10.1098/rsif.2022.0139
pmc: PMC9174718
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
20220139Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC006685
Pays : United States
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