Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats.
Alanine
Animals
Antioxidants
/ therapeutic use
Arthritis, Experimental
/ metabolism
Arthritis, Rheumatoid
/ metabolism
Aspartate Aminotransferases
C-Reactive Protein
Catalase
/ metabolism
Creatinine
Cyclohexenes
Cyclooxygenase 2
Freund's Adjuvant
Glutathione
/ metabolism
Glutathione Peroxidase
Interleukin-6
/ metabolism
Malondialdehyde
Methotrexate
/ pharmacology
NF-kappa B
/ metabolism
Rats
Terpenes
Tumor Necrosis Factor-alpha
/ metabolism
Urea
anti-inflammatory
arthritis index
oxidative stress
saffron
synovitis
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
12
03
2022
received:
10
12
2021
accepted:
30
05
2022
pubmed:
9
6
2022
medline:
20
9
2022
entrez:
8
6
2022
Statut:
ppublish
Résumé
Rheumatoid arthritis (RA) is a systemic chronic disease characterized by inflammation and synovitis. More effective treatment methods with less side effects need to be developed. In this context, current study investigated the therapeutic effects of safranal in a model of complete Freund's adjuvant (CFA)-induced RA. The control group was given 1 ml of saline orally starting from the 8th day, and 0.2 ml of CFA was given to the RA, RA + Safranal and RA + Methotrexate (MTX) groups on the 0th day of the experiment. Starting from the 8th day of the experiment, 1 ml of saline was given to the RA group, safranal was given at 200 mg/kg of body weight to the RA + MTX group, and 3 mg/kg of MTX to the RA + MTX group twice a week. The results showed that weight gain decreased in the RA group compared to the control group while arthritis index score, thymus index, and planter temperature were found to be increased. Additionally, a deterioration in blood parameters, an increase in alanine aminotransferase, aspartate aminotransferase, urea, creatinine, C-reactive protein, and malondialdehyde levels, and a decrease in reduced glutathione levels and glutathione peroxidase and catalase (CAT) activities were seen while tumor necrosis factor-α, interleukin-6 (IL-6), cyclooxygenase-2, nuclear factor kappa B levels were found to be increased. However, the safranal had a regulatory effect on all the values, except IL-6 and CAT, and blood parameters. Moreover, histopathological examination revealed that safranal reduced inflammatory cell infiltration and edema.
Substances chimiques
Antioxidants
0
Cyclohexenes
0
Interleukin-6
0
NF-kappa B
0
Terpenes
0
Tumor Necrosis Factor-alpha
0
safranal
4393FR07EA
Malondialdehyde
4Y8F71G49Q
Urea
8W8T17847W
C-Reactive Protein
9007-41-4
Freund's Adjuvant
9007-81-2
Creatinine
AYI8EX34EU
Catalase
EC 1.11.1.6
Glutathione Peroxidase
EC 1.11.1.9
Cyclooxygenase 2
EC 1.14.99.1
Aspartate Aminotransferases
EC 2.6.1.1
Glutathione
GAN16C9B8O
Alanine
OF5P57N2ZX
Methotrexate
YL5FZ2Y5U1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23140Subventions
Organisme : Mustafa Kemal Üniversitesi
ID : 20.M.030
Informations de copyright
© 2022 Wiley Periodicals LLC.
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