The dopaminergic system supports flexible and rewarding dyadic motor interactive behaviour in Parkinson's Disease.
Parkinson disease
behavioural flexibility
dopamine
interpersonal motor interactions
motivation
social behaviour
Journal
Social cognitive and affective neuroscience
ISSN: 1749-5024
Titre abrégé: Soc Cogn Affect Neurosci
Pays: England
ID NLM: 101288795
Informations de publication
Date de publication:
23 02 2023
23 02 2023
Historique:
received:
14
12
2021
revised:
21
04
2022
accepted:
07
06
2022
pubmed:
9
6
2022
medline:
3
3
2023
entrez:
8
6
2022
Statut:
ppublish
Résumé
Studies indicate that the dopaminergic system (DAS) supports individual flexible behaviour. While flexibility is quintessential to effective dyadic motor interactions, whether DAS mediates adaptations of one's own motor behaviour to that of a partner is not known. Here, we asked patients with Parkinson's Disease (PD) to synchronize their grasping movements with those of a virtual partner in conditions that did (Interactive) or did not (Cued) require to predict and adapt to its actions. PD performed the task during daily antiparkinsonian treatment ('On' condition) or after drug-withdrawal ('Off' condition). A group of healthy individuals also served as control group. In the Interactive condition, PDs performed better and found the interaction more enjoyable when in 'On' than in 'Off' condition. Crucially, PD performance in the 'On' condition did not differ from that of healthy controls. This pattern of results hints at the key role of the DAS in supporting the flexible adaptation of one's own actions to the partner's during motor interactions.
Identifiants
pubmed: 35674339
pii: 6604233
doi: 10.1093/scan/nsac040
pmc: PMC9949502
pii:
doi:
Substances chimiques
Antiparkinson Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press.
Références
J Cogn Neurosci. 2010 Dec;22(12):2702-15
pubmed: 19929761
Soc Cogn Affect Neurosci. 2018 May 1;13(5):492-500
pubmed: 29660090
Clin Neurophysiol. 2004 Aug;115(8):1821-35
pubmed: 15261861
Brain Res. 2008 Oct 31;1238:127-42
pubmed: 18760262
Nat Commun. 2015 Jul 08;6:7544
pubmed: 26154706
Soc Cogn Affect Neurosci. 2022 Feb 3;17(1):91-100
pubmed: 33448297
J Neurophysiol. 2015 Aug;114(2):1310-20
pubmed: 26133799
J Neurosci. 2015 Dec 16;35(50):16516-20
pubmed: 26674875
Brain Lang. 2003 Mar;84(3):414-23
pubmed: 12662979
Neuropsychologia. 2003;41(8):1047-57
pubmed: 12667540
Neuropsychologia. 2016 Dec;93(Pt A):106-115
pubmed: 27756693
Neuron. 2002 Jul 18;35(2):395-405
pubmed: 12160756
Neurology. 1998 Jun;50(6):1648-54
pubmed: 9633706
Cortex. 2015 Sep;70:179-88
pubmed: 25804938
Cereb Cortex. 2005 Jul;15(7):913-20
pubmed: 15459083
Neurology. 1967 May;17(5):427-42
pubmed: 6067254
Science. 2009 May 8;324(5928):811-3
pubmed: 19423830
J Neurosci. 2006 Jan 25;26(4):1133-7
pubmed: 16436599
Sci Rep. 2021 Mar 5;11(1):5321
pubmed: 33674640
Phys Life Rev. 2019 Mar;28:43-45
pubmed: 30718195
Acta Psychol (Amst). 2019 Aug;199:102891
pubmed: 31400651
Cortex. 2016 Apr;77:84-94
pubmed: 26922506
Neuroscientist. 2007 Dec;13(6):580-93
pubmed: 17911216
J Neurophysiol. 2018 Sep 1;120(3):1107-1118
pubmed: 29873613
PLoS Comput Biol. 2012 Jan;8(1):e1002327
pubmed: 22241972
Neuropsychology. 2010 Jul;24(4):542-6
pubmed: 20604628
Exp Brain Res. 2019 Dec;237(12):3363-3373
pubmed: 31728597
Neuroimage. 2014 Nov 1;101:124-37
pubmed: 24996121
Neuropsychologia. 2018 Aug;117:113-122
pubmed: 29802866
Nat Rev Neurosci. 2004 Jun;5(6):483-94
pubmed: 15152198
Neuroimage. 2001 Jul;14(1 Pt 2):S142-6
pubmed: 11373146
Mov Disord. 2014 Apr 15;29(5):597-607
pubmed: 24757109
NPJ Parkinsons Dis. 2021 Mar 2;7(1):18
pubmed: 33654110
Cereb Cortex. 2020 Mar 14;30(3):1677-1687
pubmed: 31667496
Neuropsychologia. 2016 Jan 8;80:102-114
pubmed: 26529488
Soc Cogn Affect Neurosci. 2017 Nov 1;12(11):1793-1802
pubmed: 29140533
Neuroimage. 2018 Feb 15;167:1-10
pubmed: 29146376
Trends Cogn Sci. 2012 Feb;16(2):106-13
pubmed: 22245618
Top Cogn Sci. 2009 Apr;1(2):340-52
pubmed: 25164937
Behav Res Methods. 2012 Dec;44(4):1255-65
pubmed: 22437511
Neural Netw. 2010 Oct-Nov;23(8-9):998-1003
pubmed: 20598504
Mov Disord. 2012 Jan;27(1):98-105
pubmed: 21915910
Brain Cogn. 2000 Mar;42(2):183-200
pubmed: 10744919
R Soc Open Sci. 2021 Jul 28;8(7):201205
pubmed: 34350007
J Neurosci. 2012 Jan 11;32(2):542-50
pubmed: 22238089
Brain. 2001 Dec;124(Pt 12):2503-12
pubmed: 11701603
Sci Rep. 2021 Feb 4;11(1):3060
pubmed: 33542259
J Clin Exp Neuropsychol. 1995 Dec;17(6):918-25
pubmed: 8847397
Acta Psychol (Amst). 1979 Sep;43(5):381-412
pubmed: 495175
Neuroreport. 2001 Jan 22;12(1):157-61
pubmed: 11201078
Neuropsychologia. 1989;27(11-12):1329-43
pubmed: 2615934
J Neurol Neurosurg Psychiatry. 1984 May;47(5):443-53
pubmed: 6736974
Ann Neurol. 2002 Feb;51(2):156-64
pubmed: 11835371
J Cogn Neurosci. 2015 Feb;27(2):365-76
pubmed: 25170792
Neuropsychologia. 2014 Sep;62:403-23
pubmed: 25068705
J Neurosci. 2007 Jul 4;27(27):7105-16
pubmed: 17611263
Cereb Cortex. 2022 Dec 15;33(1):222-234
pubmed: 35203090
Cereb Cortex. 2017 Feb 1;27(2):1149-1163
pubmed: 26656999
Cortex. 2020 Jun;127:131-149
pubmed: 32197149
Nat Neurosci. 2008 Sep;11(9):1109-16
pubmed: 19160510
Neuroimage. 2007;36 Suppl 2:T77-86
pubmed: 17499173
Cogn Affect Behav Neurosci. 2018 Dec;18(6):1320-1337
pubmed: 30259349
Neuropsychologia. 2017 Oct;105:92-100
pubmed: 28532704
Curr Opin Behav Sci. 2018 Feb;19:83-90
pubmed: 30035206
Sci Rep. 2015 Feb 17;5:8507
pubmed: 25687636
Acta Psychol (Amst). 2019 May;196:42-50
pubmed: 30986565
Cereb Cortex. 2020 May 14;30(5):3271-3285
pubmed: 31867672
Psychophysiology. 2018 Jun;55(6):e13057
pubmed: 29315630
J Cogn Neurosci. 2018 May;30(5):737-751
pubmed: 29308985
Parkinsonism Relat Disord. 2010 Aug;16(7):466-70
pubmed: 20538499
Neuropsychologia. 2009 Jan;47(2):406-14
pubmed: 18845171
Cogn Behav Neurol. 2003 Dec;16(4):193-210
pubmed: 14665819
Psychol Res. 2020 Apr;84(3):810-822
pubmed: 30191316
Neuron. 2016 Feb 3;89(3):430-2
pubmed: 26844827
J Cogn Neurosci. 2022 Mar 31;34(5):897-915
pubmed: 35171250
Nat Commun. 2020 Oct 16;11(1):5233
pubmed: 33067461
J Neurosci. 2016 Jan 13;36(2):268-79
pubmed: 26758821
Neuroscience. 2022 Mar 15;486:103-125
pubmed: 33516775
Soc Cogn Affect Neurosci. 2014 Aug;9(8):1062-8
pubmed: 23709353
PLoS One. 2016 Mar 02;11(3):e0149836
pubmed: 26934579