Investigational PET tracers in neuro-oncology-What's on the horizon? A report of the PET/RANO group.

Humans Radiopharmaceuticals Positron-Emission Tomography / methods Brain Neoplasms / metabolism
Immuno-PET PSMA TSPO fluciclovine somatostatin

Journal

Neuro-oncology
ISSN: 1523-5866
Titre abrégé: Neuro Oncol
Pays: England
ID NLM: 100887420

Informations de publication

Date de publication:
02 11 2022
Historique:
pubmed: 9 6 2022
medline: 4 11 2022
entrez: 8 6 2022
Statut: ppublish

Résumé

Many studies in patients with brain tumors evaluating innovative PET tracers have been published in recent years, and the initial results are promising. Here, the Response Assessment in Neuro-Oncology (RANO) PET working group provides an overview of the literature on novel investigational PET tracers for brain tumor patients. Furthermore, newer indications of more established PET tracers for the evaluation of glucose metabolism, amino acid transport, hypoxia, cell proliferation, and others are also discussed. Based on the preliminary findings, these novel investigational PET tracers should be further evaluated considering their promising potential. In particular, novel PET probes for imaging of translocator protein and somatostatin receptor overexpression as well as for immune system reactions appear to be of additional clinical value for tumor delineation and therapy monitoring. Progress in developing these radiotracers may contribute to improving brain tumor diagnostics and advancing clinical translational research.

Identifiants

DOI: 10.1093/neuonc/noac131 PMID: 35674736 PMC: PMC9629449
pubmed: 35674736
pii: 6604341
doi: 10.1093/neuonc/noac131
pmc: PMC9629449
doi:

Substances chimiques

Radiopharmaceuticals 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1815-1826

Informations de copyright

© The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Auteurs

Norbert Galldiks (N)

Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.
Institute of Neuroscience and Medicine (INM-3, -4), Research Center Juelich, Juelich, Germany.
Center of Integrated Oncology (CIO), Universities of Aachen, Bonn, Cologne, and Düsseldorf, Germany.
ORCID: 0000-0002-2485-1796

Karl-Josef Langen (KJ)

Institute of Neuroscience and Medicine (INM-3, -4), Research Center Juelich, Juelich, Germany.
Center of Integrated Oncology (CIO), Universities of Aachen, Bonn, Cologne, and Düsseldorf, Germany.
Department of Nuclear Medicine, University Hospital RWTH Aachen, Aachen, Germany.

Nathalie L Albert (NL)

Department of Nuclear Medicine, Ludwig Maximilians-University of Munich, Munich, Germany.
German Cancer Consortium (DKTK), Partner Site Munich, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Ian Law (I)

Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Michelle M Kim (MM)

Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.

Javier E Villanueva-Meyer (JE)

Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.

Riccardo Soffietti (R)

Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy.
ORCID: 0000-0002-9204-7038

Patrick Y Wen (PY)

Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts, USA.

Michael Weller (M)

Department of Neurology, Clinical Neuroscience Center University Hospital and University of Zurich, Zurich, Switzerland.
ORCID: 0000-0002-1748-174X

Joerg C Tonn (JC)

Department of Neurosurgery, University Hospital of Munich (LMU), Munich, Germany.
German Cancer Consortium (DKTK), Partner Site Munich, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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