Correlation of somatostatin receptor PET/CT imaging features and immunohistochemistry in neuroendocrine tumors of the lung: a retrospective observational study.

Carcinoid Tumor Fluorodeoxyglucose F18 Gallium Radioisotopes Humans Immunohistochemistry Ki-67 Antigen Lung / pathology Lung Neoplasms / diagnostic imaging Neuroendocrine Tumors / diagnostic imaging Organometallic Compounds Positron Emission Tomography Computed Tomography Receptors, Somatostatin / analysis Retrospective Studies Somatostatin
Immunohistochemistry Ki-67 Lung NET PET/CT Somatostatin receptor subtypes [68Ga]-DOTA-somatostatin analogs

Journal

European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988

Informations de publication

Date de publication:
Oct 2022
Historique:
received: 18 01 2022
accepted: 22 05 2022
pubmed: 9 6 2022
medline: 5 10 2022
entrez: 8 6 2022
Statut: ppublish

Résumé

To correlate somatostatin receptor (SSTR) and proliferative activity profile (SSTR2, SSTR5, Ki-67) at immunohistochemistry (IHC) with SSTR-PET/CT imaging features in a retrospective series of lung neuroendocrine tumors (NET). Proliferative activity by Ki-67 and Among 551 patients who underwent SSTR-PET/CT with Definitive diagnosis consisted of 26 typical carcinoids-G1 and six atypical carcinoids-G2. Positive SSTR2-IHC was found in 62.5% of samples while SSTR5-IHC positivity was 19.4%. A correlation between SSTR2-IHC and SSTR-PET/CT was found in 24/32 cases (75.0%, p = 0.003): 20 were concordantly positive, 4 concordantly negative. For positive IHC, 100% concordance with SSTR-PET/CT (both positive) was observed, while for negative IHC concordance (both negative) was 33.3%. In 8 cases, IHC was negative while SSTR-PET/CT was positive, even though with low-grade uptake in all but one. A significant correlation between SUV This retrospective study showed an overall good agreement between SSTR2-IHC and tumor uptake at SSTR-PET/CT in lung NETs. SSTR-PET/CT SUV

Identifiants

DOI: 10.1007/s00259-022-05848-z PMID: 35674739 PMC: PMC9525360
pubmed: 35674739
doi: 10.1007/s00259-022-05848-z
pii: 10.1007/s00259-022-05848-z
pmc: PMC9525360
doi:

Substances chimiques

Gallium Radioisotopes 0
Ki-67 Antigen 0
Organometallic Compounds 0
Receptors, Somatostatin 0
Fluorodeoxyglucose F18 0Z5B2CJX4D
Somatostatin 51110-01-1

Types de publication

Journal Article Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

4182-4193

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2022. The Author(s).

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Auteurs

Vittoria Rufini (V)

Section of Nuclear Medicine, University Department of Radiological Sciences and Hematology, Università Cattolica del Sacro Cuore, Rome, Italy. Vittoria.Rufini@unicatt.it.
Unit of Nuclear Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. Vittoria.Rufini@unicatt.it.
ENETS Center of Excellence for the Diagnosis and Cure of Neuroendocrine Tumors, Rome, Italy. Vittoria.Rufini@unicatt.it.
ORCID: 0000-0002-1045-0633

Margherita Lorusso (M)

ENETS Center of Excellence for the Diagnosis and Cure of Neuroendocrine Tumors, Rome, Italy.
PET/CT Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Frediano Inzani (F)

ENETS Center of Excellence for the Diagnosis and Cure of Neuroendocrine Tumors, Rome, Italy.
Unit of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Tina Pasciuto (T)

Research Core Facility Data Collection G-STeP, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Elizabeth Katherine Anna Triumbari (EKA)

Section of Nuclear Medicine, University Department of Radiological Sciences and Hematology, Università Cattolica del Sacro Cuore, Rome, Italy.

Lucia Rosalba Grillo (LR)

Pathology Unit, San Camillo-Forlanini Hospitals, Rome, Italy.

Filippo Locco (F)

Section of Thoracic Surgery, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Unit of Thoracic Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Stefano Margaritora (S)

Section of Thoracic Surgery, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Unit of Thoracic Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Edoardo Pescarmona (E)

Pathology Unit, 'Regina Elena' National Cancer Institute IRCCS, Rome, Italy.

Guido Rindi (G)

ENETS Center of Excellence for the Diagnosis and Cure of Neuroendocrine Tumors, Rome, Italy.
Unit of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Section of Pathology, Department of Woman and Child Health and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Tumeur carcinoïde › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Glucides › Désoses › Désoxyglucose › Fluorodésoxyglucose F18 › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Gallium › Isotopes du gallium › Radio-isotopes du gallium › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Antigène KI-67 › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Appareil respiratoire › Poumon › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Composés chimiques organiques › Composés organométalliques › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormones hypothalamiques hypophysotropes régulatrices › Récepteur somatostatine › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Correlation of somatostatin receptor PET/CT...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormones hypothalamiques hypophysotropes inhibitrices › Somatostatine › Correlation of somatostatin receptor PET/CT...