Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer-a preclinical study.
ADP Ribose Transferases
/ administration & dosage
Animals
Antibodies, Monoclonal
/ administration & dosage
Bacterial Toxins
/ administration & dosage
Breast Neoplasms
/ therapy
Carcinoma, Intraductal, Noninfiltrating
/ therapy
Exotoxins
/ administration & dosage
Female
Humans
Immunotoxins
/ administration & dosage
MCF-7 Cells
Mice
Mice, Inbred NOD
Mice, SCID
Molecular Targeted Therapy
Receptors, Transferrin
/ metabolism
Virulence Factors
/ administration & dosage
Pseudomonas aeruginosa Exotoxin A
immunotoxin
intraductal
mammary
mouse
tumor
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
14 06 2022
14 06 2022
Historique:
entrez:
8
6
2022
pubmed:
9
6
2022
medline:
11
6
2022
Statut:
ppublish
Résumé
The human transferrin receptor (TFR) is overexpressed in most breast cancers, including preneoplastic ductal carcinoma in situ (DCIS). HB21(Fv)-PE40 is a single-chain immunotoxin (IT) engineered by fusing the variable region of a monoclonal antibody (HB21) against a TFR with a 40 kDa fragment of
Identifiants
pubmed: 35675429
doi: 10.1073/pnas.2200200119
pmc: PMC9214490
doi:
Substances chimiques
Antibodies, Monoclonal
0
Bacterial Toxins
0
Exotoxins
0
Immunotoxins
0
Receptors, Transferrin
0
Virulence Factors
0
ADP Ribose Transferases
EC 2.4.2.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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