Altered predictive control during memory suppression in PTSD.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
08 06 2022
08 06 2022
Historique:
received:
08
10
2021
accepted:
20
05
2022
entrez:
8
6
2022
pubmed:
9
6
2022
medline:
11
6
2022
Statut:
epublish
Résumé
Aberrant predictions of future threat lead to maladaptive avoidance in individuals with post-traumatic stress disorder (PTSD). How this disruption in prediction influences the control of memory states orchestrated by the dorsolateral prefrontal cortex is unknown. We combined computational modeling and brain connectivity analyses to reveal how individuals exposed and nonexposed to the 2015 Paris terrorist attacks formed and controlled beliefs about future intrusive re-experiencing implemented in the laboratory during a memory suppression task. Exposed individuals with PTSD used beliefs excessively to control hippocampal activity during the task. When this predictive control failed, the prediction-error associated with unwanted intrusions was poorly downregulated by reactive mechanisms. This imbalance was linked to higher severity of avoidance symptoms, but not to general disturbances such as anxiety or negative affect. Conversely, trauma-exposed participants without PTSD and nonexposed individuals were able to optimally balance predictive and reactive control during the memory suppression task. These findings highlight a potential pathological mechanism occurring in individuals with PTSD rooted in the relationship between the brain's predictive and control mechanisms.
Identifiants
pubmed: 35676268
doi: 10.1038/s41467-022-30855-x
pii: 10.1038/s41467-022-30855-x
pmc: PMC9177681
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3300Informations de copyright
© 2022. The Author(s).
Références
Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6666-6674
pubmed: 28611219
Nat Commun. 2022 Jun 8;13(1):3300
pubmed: 35676268
Q J Exp Psychol A. 2005 Feb;58(2):193-233
pubmed: 15903115
Trends Cogn Sci. 2017 Jun;21(6):425-433
pubmed: 28476348
PLoS Comput Biol. 2014 Jan;10(1):e1003441
pubmed: 24465198
Comput Psychiatr. 2018 Feb 01;2:50-73
pubmed: 30090862
Neuroimage Clin. 2018 May 16;19:581-598
pubmed: 29984166
Nat Commun. 2016 Mar 29;7:10996
pubmed: 27020312
Neuroimage. 2003 Feb;18(2):293-309
pubmed: 12595184
Elife. 2018 Jan 09;7:
pubmed: 29313489
Front Psychol. 2012 Mar 05;3:59
pubmed: 22403563
Neurobiol Learn Mem. 2016 Oct;134 Pt A:145-161
pubmed: 26642918
Trends Neurosci. 2019 Oct;42(10):727-739
pubmed: 31506189
Nat Neurosci. 2000 Nov;3 Suppl:1218-23
pubmed: 11127841
PLoS One. 2010 Dec 14;5(12):e15554
pubmed: 21179480
Hippocampus. 2015 Mar;25(3):393-405
pubmed: 25331166
Nature. 2015 Sep 10;525(7568):243-6
pubmed: 26322583
Arch Gen Psychiatry. 2011 Jul;68(7):701-13
pubmed: 21727254
Biol Psychiatry. 2009 Dec 15;66(12):1072-4
pubmed: 19944792
Nat Rev Neurosci. 2018 Dec;19(12):744-757
pubmed: 30356103
Front Hum Neurosci. 2011 May 02;5:39
pubmed: 21629826
Nat Neurosci. 2019 Mar;22(3):334-336
pubmed: 30796421
Elife. 2018 Aug 16;7:
pubmed: 30113310
Neuroimage. 2003 Aug;19(4):1273-302
pubmed: 12948688
PLoS Comput Biol. 2010 Mar 12;6(3):e1000709
pubmed: 20300649
J Trauma Stress. 2015 Dec;28(6):489-98
pubmed: 26606250
Neuroimage. 2016 Nov 1;141:469-489
pubmed: 27477536
Compr Psychiatry. 2002 Nov-Dec;43(6):413-9
pubmed: 12439826
Trends Cogn Sci. 2017 Aug;21(8):573-576
pubmed: 28583416
J Neurosci. 2017 Jul 5;37(27):6423-6441
pubmed: 28559378
Perspect Psychol Sci. 2011 May;6(3):291-8
pubmed: 26168519
Prog Neurobiol. 2020 Sep;192:101821
pubmed: 32446883
Trends Cogn Sci. 2012 Feb;16(2):106-13
pubmed: 22245618
Science. 2020 Feb 14;367(6479):
pubmed: 32054733
Neurosci Biobehav Rev. 2020 Jun;113:448-460
pubmed: 32315695
Behav Brain Res. 2020 Jan 13;377:112243
pubmed: 31539574
Annu Rev Psychol. 2000;51:59-91
pubmed: 10751965
Neuron. 2012 Oct 18;76(2):450-60
pubmed: 23083745
Neurosci Biobehav Rev. 2014 Oct;46 Pt 1:30-43
pubmed: 24929218
Elife. 2019 Nov 26;8:
pubmed: 31769410
Biol Psychiatry. 2015 Sep 1;78(5):290-7
pubmed: 26238378
PLoS One. 2014 Sep 11;9(9):e106953
pubmed: 25211489
Biol Psychiatry. 2015 Sep 1;78(5):336-43
pubmed: 25981173
Memory. 2004 Jul;12(4):403-15
pubmed: 15487537
Nat Commun. 2017 Nov 3;8(1):1311
pubmed: 29101315
JAMA Psychiatry. 2018 Feb 1;75(2):201-209
pubmed: 29197929
Brain Connect. 2011;1(1):13-36
pubmed: 22432952
Behav Res Ther. 2000 Apr;38(4):319-45
pubmed: 10761279
Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1310-9
pubmed: 24639546
Nat Neurosci. 2019 Mar;22(3):470-476
pubmed: 30664770
Psychol Rev. 2010 Jan;117(1):210-32
pubmed: 20063969
Anxiety Stress Coping. 2016 Sep;29(5):497-506
pubmed: 26275127
Neuroimage. 2014 Dec;103:65-74
pubmed: 25224995
Nat Commun. 2016 Mar 15;7:11003
pubmed: 26977589
Neuroimage. 2007 Jan 1;34(1):220-34
pubmed: 17055746
Neuroimage. 2000 Oct;12(4):466-77
pubmed: 10988040
Nat Rev Neurosci. 2013 Jul;14(7):488-501
pubmed: 23783199
Cereb Cortex. 2016 Apr;26(4):1634-1646
pubmed: 25601236
Int J Psychophysiol. 2015 Dec;98(3 Pt 2):594-605
pubmed: 25462219
Psychon Bull Rev. 2003 Sep;10(3):638-44
pubmed: 14620358
Cereb Cortex. 2016 Aug;26(8):3508-26
pubmed: 27230218
Neuroimage. 2014 Jan 1;84:971-85
pubmed: 24018303