Xenotransplantation of Human Spermatogonia Into Various Mouse Recipient Models.

germ cells human pluripotent stem cells immunecompetent mouse spermatogonial stem cells transplantation

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2022
Historique:
received: 24 02 2022
accepted: 20 04 2022
entrez: 9 6 2022
pubmed: 10 6 2022
medline: 10 6 2022
Statut: epublish

Résumé

Spermatogonial stem cells are the foundation of continuous spermatogenesis in adult mammals. Xenograft models have been established to define human SSCs, mostly using infertile and immune-deficient mice as the recipients for human germ cell transplantation. However, it is time-consuming to prepare such recipients using irradiation or chemotherapeutic agents, and this approach may also introduce confounding factors when residual endogenous germ cells recover in transplanted recipients. It remains to be determined whether immune-competent genetically infertile mice can be suitable recipients for xenotransplantation. In this study, we observed similar engraftment efficiencies when using spermatogonia from human biopsied testes across immune-deficient nude mice, immune-competent ICR mice, and genetically infertile

Identifiants

pubmed: 35676935
doi: 10.3389/fcell.2022.883314
pii: 883314
pmc: PMC9168328
doi:

Types de publication

Journal Article

Langues

eng

Pagination

883314

Informations de copyright

Copyright © 2022 Liang, Sun, Zhu, Wang, Ye, Li and Wang.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Dongli Liang (D)

Laboratory Animal Center, Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai, China.

Qi Sun (Q)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Zijue Zhu (Z)

Department of Andrology, The Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Chuanyun Wang (C)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Shicheng Ye (S)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Zheng Li (Z)

Department of Andrology, The Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Yuan Wang (Y)

Department of Animal Sciences, College of Agriculture and Natural Resources, Michigan State University, East Lansing, MI, United States.

Classifications MeSH