Neutropenia, neutrophilia, and neutrophil-lymphocyte ratio as prognostic markers in patients with metastatic castration-resistant prostate cancer.

Background and purpose

Chemotherapy-induced neutropenia and neutrophil-to-lymphocyte ratio (NLR) are potentially useful prognostic markers in patients with metastatic castration-resistant prostate cancer (mCRPC). This post hoc analysis investigated whether these markers can be utilized for dose considerations and evaluated the prognostic impact of leukocyte subtypes.

Patients and methods

PROSELICA assessed the non-inferiority of cabazitaxel 20 mg/m

Results

PROSELICA confirmed the negative prognostic value of increased baseline NLR [⩾3, hazard ratio (HR) 1.40;

Conclusions

Grade ⩾ 3 neutropenia was the only leukocyte-based biomarker associated with all key outcome parameters in mCRPC patients receiving cabazitaxel and might be able to overcome the negative prognostic effect of baseline neutrophilia.

NCT number

NCT01308580.

Informations de copyright

© The Author(s), 2022.

Déclaration de conflit d'intérêts

Conflict of interest statement: The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: AM has provided a consulting, advisory or speaker role for Amgen, Astellas, Boehringer Ingelheim, Celgene, Janssen, Gerresheimer, Glaxo-Smith-Kline, Merck, MSD, Novartis, Roche, Sanofi, Servier, Takeda, and Vifor, has received research funding from Bayer (personal) and Merck & Cie (institutional), has intellectual property interests relating to Merck (not related to this report), has been paid to provide expert testimony for Sanofi, and has reported travel/accommodation expenses paid for by Amgen, Astellas, Boehringer Ingelheim, Janssen, Merck, Roche, Sanofi, and Servier. RdW has provided a consulting or advisory role for Sanofi, Merck Sharp & Dohme, Roche/Genetech, Janssen, Bayer and Clovis Oncology. RdW has also received honoraria and/or research funding from Sanofi and Bayer. SO has provided a consulting or advisory role for AstraZeneca, Sanofi, Roche/Genetech, Janssen, Bayer and Astellas, Pfizer, Merck Sharp & Dohme, Novartis, Bristol Myers Squib. SO has also received honoraria and/or research funding from Sanofi, AstraZeneca, Bayer, Pfizer, Janssen, and Bristol Myers Squib. OS has provided a consulting role for Advanced Accelerator Applications (AAA), Astellas, AstraZeneca, Bayer, Blue Earth Diagnostics, Inc., Bavarian Nordic, Bristol Myers Squibb, Clarity Pharmaceuticals, Clovis, Constellation, Dendreon, EMD Serono, Fusion, Isotopen Technologien Meunchen, Janssen, Merck, Moyvant, Myriad, Noria Therapeutics, Inc., Novartis, Noxopharm, Progenics, POINT Biopharma, Pfizer, Sanofi, Tenebio, Telix, Theragnostics. OS has received grant/research support from Advanced Accelerator Applications, Amgen, AstraZeneca, Bayer, Constellation, Endocyte, Invitae, Janssen, Lantheus, Merck, Progenics, and Tenebio. FS-L has provided a consulting or advisory role for Bayer, BMS, Janssen, MSD, AstraZeneca and Sanofi. FS-L has also reported travel/other expenses from BMS, Sanofi, and Roche. ZS was an employee of Sanofi. MF and AO are current/former Sanofi employees. AO owns stocks in Sanofi. ME is on the board of directors for VERU Inc. JSdB has provided a consulting or advisory role for AstraZeneca, Sanofi, Roche, Astellas Pharma, Bayer, Pfizer, Merck Sharp & Dohme, Merck Serono, Boehringer Ingelheim, Sierra Oncology, Menarini Silicon Biostystems, Celgene, Taiho Pharmaceuticals, Daiichi Sankyo, Janssen, Genmab, GSK, Orion Pharma GmbH, Eisai, and BioXCel therapeutics, and received travel/accommodation/expenses from AstraZeneca, Astellas Pharma, GSK, Orion Pharma GmbH, Sanofi, Genmab, Taiho Pharmaceuticals, Qiagen, and Vertex. JSdB is also associated with patents/royalties/other IP for abiraterone, PARP inhibitors, IL-23 targeting in prostate cancer, CHK1 inhibitor. JSdB has also received honoraria and/or research funding from AstraZeneca, Sanofi, Astellas Pharma, Pfizer, Roche/Genentech, Janssen, Menarini Silicon Biosystems, Daiichi Sankyo, Sierra Oncology, Taiho Pharmaceuticals, Merck Serono, Astex Pharmaceuticals, Merck Sharp & Dohme, Orion Pharma GmbH, CellCentric, Celgene, Bayer, MedImmune, Medivation, and BioExcel.