IL-33 promotes gastric tumour growth in concert with activation and recruitment of inflammatory myeloid cells.
IL-33
gastric cancer
macrophages
mast cells
tumorigenesis
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
04
2022
accepted:
07
05
2022
entrez:
9
6
2022
pubmed:
10
6
2022
medline:
10
6
2022
Statut:
epublish
Résumé
Interleukin-33 (IL-33) is an IL-1 family cytokine known to promote T-helper (Th) type 2 immune responses that are often deregulated in gastric cancer (GC). IL-33 is overexpressed in human gastric tumours suggesting a role in driving GC progression although a causal link has not been proven. Here, we investigated the impact of IL-33 genetic deficiency in the well-characterized
Identifiants
pubmed: 35677533
doi: 10.18632/oncotarget.28238
pii: 28238
pmc: PMC9159270
doi:
Substances chimiques
Cytokines
0
IL33 protein, human
0
Il33 protein, mouse
0
Interleukin-1 Receptor-Like 1 Protein
0
Interleukin-33
0
Cytokine Receptor gp130
133483-10-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
785-799Informations de copyright
Copyright: © 2022 Tran et al.
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST Authors have no conflicts of interest to declare.
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