Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors.
aging
deep phenotyping
pulse wave velocity (PWV)
starvation
supernormal vascular aging
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
12
2021
accepted:
18
02
2022
entrez:
9
6
2022
pubmed:
10
6
2022
medline:
10
6
2022
Statut:
epublish
Résumé
Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.
Identifiants
pubmed: 35677697
doi: 10.3389/fcvm.2022.843439
pmc: PMC9170230
doi:
Types de publication
Case Reports
Langues
eng
Pagination
843439Informations de copyright
Copyright © 2022 Rotar, Boyarinova, Moguchaya, Tolkunova, Kolosov, Rezapova, Freylikhman, Usoltsev, Melnik, Sergushichev, Solntsev, Kostareva, Dubinina, Voortman, Stevens, Daly, Konradi, Shlyakhto and Artomov.
Déclaration de conflit d'intérêts
MD is a founder of Maze Therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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