Lower Circulating Leptin Levels Are Related to Non-Alcoholic Fatty Liver Disease in Children With Obesity.
NAFLD
children
leptin
obesity
partial leptin deficiency
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
02
2022
accepted:
04
04
2022
entrez:
9
6
2022
pubmed:
10
6
2022
medline:
11
6
2022
Statut:
epublish
Résumé
While for individuals with obesity an association between hyperleptinemia and an increased risk of non-alcoholic fatty liver disease (NAFLD) is assumed, a leptin deficiency is also related to the development of NAFLD early in life in To investigate the association of circulating leptin levels in pre-pubertal children with obesity and steatosis hepatis. The cross-sectional study consisted data of n=97 (n One-third of the children with obesity were diagnosed with steatosis hepatis (I°: 63.6%, II°/III°: 36.4%). Children with steatosis hepatis had significantly lower z-scores of circulating leptin levels compared to children with an unremarkable liver ultrasonography (-2.1 ± 0.8 vs. -0.7 ± 0.6). Z-scores of circulating leptin levels correlate negatively with degree of steatosis hepatis. Children with low z-scores of circulating leptin levels had significantly higher triglyceride, fasting insulin and c-peptide levels compared to children with normal z-scores of circulating leptin levels. Prepubertal children with NAFLD and obesity and partial leptin deficiency might be defined as a clinical subgroup.
Sections du résumé
Background
While for individuals with obesity an association between hyperleptinemia and an increased risk of non-alcoholic fatty liver disease (NAFLD) is assumed, a leptin deficiency is also related to the development of NAFLD early in life in
Objectives
To investigate the association of circulating leptin levels in pre-pubertal children with obesity and steatosis hepatis.
Methods
The cross-sectional study consisted data of n=97 (n
Results
One-third of the children with obesity were diagnosed with steatosis hepatis (I°: 63.6%, II°/III°: 36.4%). Children with steatosis hepatis had significantly lower z-scores of circulating leptin levels compared to children with an unremarkable liver ultrasonography (-2.1 ± 0.8 vs. -0.7 ± 0.6). Z-scores of circulating leptin levels correlate negatively with degree of steatosis hepatis. Children with low z-scores of circulating leptin levels had significantly higher triglyceride, fasting insulin and c-peptide levels compared to children with normal z-scores of circulating leptin levels.
Conclusion
Prepubertal children with NAFLD and obesity and partial leptin deficiency might be defined as a clinical subgroup.
Identifiants
pubmed: 35677722
doi: 10.3389/fendo.2022.881982
pmc: PMC9169562
doi:
Substances chimiques
C-Peptide
0
Insulin
0
Leptin
0
Triglycerides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
881982Informations de copyright
Copyright © 2022 Brandt, von Schnurbein, Denzer, Kratzer and Wabitsch.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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