Multi-Epitope Protein as a Tool of Serological Diagnostic Development for HTLV-1 and HTLV-2 Infections.
HTLV-1
HTLV-2
co-infections
multi-epitope protein
serological diagnostic
Journal
Frontiers in public health
ISSN: 2296-2565
Titre abrégé: Front Public Health
Pays: Switzerland
ID NLM: 101616579
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
02
2022
accepted:
11
04
2022
entrez:
9
6
2022
pubmed:
10
6
2022
medline:
11
6
2022
Statut:
epublish
Résumé
A multi-epitope protein expressed in a prokaryotic system, including epitopes of Env, Gag, and Tax proteins of both HTLV-1 and HTLV-2 was characterized for HTLV-1/2 serological screening. This tool can contribute to support the implementation of public policies to reduce HTLV-1/2 transmission in Brazil, the country with the highest absolute numbers of HTLV-1/2 infected individuals. The chimeric protein was tested in EIA using serum/plasma of HTLV-infected individuals and non-infected ones from four Brazilian states, including the North and Northeast regions (that present high prevalence of HTLV-1/2) and Southeast region (that presents intermediate prevalence rates) depicting different epidemiological context of HTLV-1/2 infection in our country. We enrolled samples from Pará (
Identifiants
pubmed: 35677763
doi: 10.3389/fpubh.2022.884701
pmc: PMC9168532
doi:
Substances chimiques
Epitopes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
884701Informations de copyright
Copyright © 2022 Franco, Rocha, Cox, Daian e Silva, da Silveira e Santos, Martins, Romanelli, Ishak, Vallinoto, Bomfim, Caterino-de-Araujo, Coelho-dos-Reis, da Fonseca and Barbosa-Stancioli.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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