A Prospective Longitudinal Study of Early Childhood Caries Onset in Initially Caries-Free Children.
Candida
Lactobacillus
Streptococcus mutans
caries-free children
salivary IgA
salivary cortisol
Journal
JDR clinical and translational research
ISSN: 2380-0852
Titre abrégé: JDR Clin Trans Res
Pays: United States
ID NLM: 101684997
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
medline:
18
9
2023
pubmed:
10
6
2022
entrez:
9
6
2022
Statut:
ppublish
Résumé
Early childhood caries (ECC) is a complex oral disease that is prevalent in US children. The purpose of this 2-y prospective cohort study was to examine baseline and time-dependent risk factors for ECC onset in initially caries-free preschool children. A cohort of 189 initially caries-free children aged 1 to 3 y was recruited. At each 6-mo study visit, children were examined using the ICDAS index; salivary samples were collected to assess mutans streptococci (MS), lactobacilli, Onset of ECC was associated with high salivary MS levels at baseline (log-rank test, Our results provide prospective evidence that an increase in salivary MS predicts ECC onset in young, initially caries-free children, confirming that a high salivary MS count likely plays a causal role in ECC onset, independent of covariates. These results suggest that we must focus on reducing salivary MS counts in young children and preventing or delaying MS colonization in infants and young children determined to be at risk for ECC.
Identifiants
pubmed: 35678084
doi: 10.1177/23800844221101800
pmc: PMC10504875
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
394-401Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE024985
Pays : United States
Références
Scand J Dent Res. 1978 Jul;86(4):221-30
pubmed: 30166
Child Dev. 1993 Oct;64(5):1439-50
pubmed: 8222882
Caries Res. 2009;43(1):25-35
pubmed: 19136829
Int J Paediatr Dent. 2013 Jan;23(1):23-31
pubmed: 22251427
Community Dent Oral Epidemiol. 2007 Jun;35(3):170-8
pubmed: 17518963
Pediatr Dent. 2019 Mar 15;41(2):95-112
pubmed: 30992106
Vital Health Stat 11. 2007 Apr;(248):1-92
pubmed: 17633507
Community Dent Oral Epidemiol. 1998;26(1 Suppl):8-27
pubmed: 9671196
Dev Psychobiol. 2013 Mar;55(2):145-55
pubmed: 22315044
PLoS One. 2016 Oct 14;11(10):e0164242
pubmed: 27741258
BMC Oral Health. 2019 Feb 18;19(1):34
pubmed: 30777062
Community Dent Oral Epidemiol. 2004 Jun;32(3):201-9
pubmed: 15151690
P R Health Sci J. 2011 Dec;30(4):165-6
pubmed: 22263295
Behav Res Ther. 1990;28(6):487-95
pubmed: 2076086
Caries Res. 1989;23(3):190-4
pubmed: 2660999
Control Clin Trials. 2000 Dec;21(6):552-60
pubmed: 11146149
Pediatr Dent. 2015 May-Jun;37(3):217-25
pubmed: 26063551
Pediatr Dent. 2008 Jul-Aug;30(4):329-33
pubmed: 18767513
JDR Clin Trans Res. 2022 Apr;7(2):163-173
pubmed: 33719664
Pediatr Dent. 2021 May 15;43(3):176-194
pubmed: 34172110
Caries Res. 2012;46(4):385-93
pubmed: 22699390
Soc Sci Med. 2010 Nov;71(9):1644-52
pubmed: 20870333
Arch Oral Biol. 1996 Nov;41(11):1011-8
pubmed: 9068865
J Clin Microbiol. 1980 Sep;12(3):475-6
pubmed: 7012183
J Am Dent Assoc. 2017 Aug;148(8):550-565.e7
pubmed: 28619207
Scand J Dent Res. 1987 Feb;95(1):13-7
pubmed: 3470893
Caries Res. 2018;52(1-2):102-112
pubmed: 29262404
J Dent Res. 2020 Jun;99(6):703-712
pubmed: 32109360
Caries Res. 2010;44(3):272-6
pubmed: 20516688
Pediatr Dent. 2016;38(4):325-30
pubmed: 27557922
Med Care. 2009 Nov;47(11):1121-8
pubmed: 19786919
Caries Res. 2013;47(2):117-27
pubmed: 23207628
J Consult Clin Psychol. 1989 Dec;57(6):732-40
pubmed: 2600244