Chemical Constituents of the Stem Bark of the Hybrid Plant Citrus × paradisi Macfad. (Rutaceae).
Citrus paradise
Rutaceae
cytotoxicity
hydrogenation
limonoids
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
27
12
2021
accepted:
17
05
2022
pubmed:
10
6
2022
medline:
28
7
2022
entrez:
9
6
2022
Statut:
ppublish
Résumé
The stem bark of Citrus × paradisi Macfad. (Rutaceae) gave (23S)-isolimonexic acid (1), limonin (2), citracridone II (3), citpressine II (4), citpressine I (5), grandisine (6), 2-hydroxynoracronycine (7), citracridone I (8), 5-methoxyseselin (9), umbelliferone (10), scopoletin (11), naringenin (12), apigenin (13), friedelin (14), agrostophyllinone (15) and stigmasterol-3-O-β-D-glucopyranoside (16). The structures of the compounds were determined using NMR and MS spectroscopic data, and by comparison with published data. The relative configuration of 1 was proposed as (23S)-isolimonexic acid using NOE studies. Hydrogenation reaction of compound 3 led to the new derivative 3',4'-dihydrocitracridone II (3a). Cytotoxicity activities against the human adenocarcinoma alveolar basal epithelial cell lines A549 and the Caucasian prostate adenocarcinoma cell lines PC3, using the MTT assays showed that the methanol crude extract was significant with IC
Identifiants
pubmed: 35678514
doi: 10.1002/cbdv.202101033
doi:
Substances chimiques
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202101033Subventions
Organisme : Alexander von Humboldt Foundation, Germany
Organisme : Yaoundé-Bielefeld Bilateral Graduate School of Natural Products
Informations de copyright
© 2022 Wiley-VHCA AG, Zurich, Switzerland.
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