Cellular mechanisms mediating activity-dependent extracellular space shrinkage in the retina.
AQP4 channels
Müller cells
Na+/HCO3− cotransporter
Na+/K+/2Cl− cotransporter
extracellular space
glial cells
inwardly rectifying K+ channels
monocarboxylate transporter
retina
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
25
05
2022
received:
15
02
2022
accepted:
26
05
2022
pubmed:
10
6
2022
medline:
17
8
2022
entrez:
9
6
2022
Statut:
ppublish
Résumé
Volume transmission plays an essential role in CNS function, with neurotransmitters released from synapses diffusing through the extracellular space (ECS) to distant sites. Changes in the ECS volume fraction (α) will influence the diffusion and the concentration of transmitters within the ECS. We have recently shown that neuronal activity evoked by physiological photic stimuli results in rapid decreases in ECS α as large as 10% in the retina. We now characterize the cellular mechanisms responsible for this ECS shrinkage. We find that block of inwardly rectifying K
Identifiants
pubmed: 35678626
doi: 10.1002/glia.24228
pmc: PMC9378592
mid: NIHMS1811875
doi:
Substances chimiques
Bumetanide
0Y2S3XUQ5H
Sodium
9NEZ333N27
Potassium
RWP5GA015D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1927-1937Subventions
Organisme : NEI NIH HHS
ID : P30 EY011374
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026514
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026882
Pays : United States
Informations de copyright
© 2022 The Authors. GLIA published by Wiley Periodicals LLC.
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