Cognitive functioning, cerebrospinal fluid Alzheimer's disease biomarkers and cerebral glucose metabolism in late-onset epilepsy of unknown aetiology: A prospective study.
Humans
Aged
Alzheimer Disease
/ metabolism
tau Proteins
/ cerebrospinal fluid
Prospective Studies
Amyloid beta-Peptides
/ metabolism
Cognitive Dysfunction
Cognition
Fluorodeoxyglucose F18
Positron-Emission Tomography
/ methods
Biomarkers
/ metabolism
Epilepsy
Glucose
Peptide Fragments
/ cerebrospinal fluid
anti-seizure medication
cognition
positron emission tomography
tau proteins
β-amyloid42
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
16
05
2022
received:
31
10
2021
accepted:
04
06
2022
pubmed:
10
6
2022
medline:
16
11
2022
entrez:
9
6
2022
Statut:
ppublish
Résumé
Epilepsy is increasing, being more common in older adults, with more than 20% of late-onset cases with unknown aetiology (LOEU). Although epilepsy was associated with cognitive impairment, few studies evaluated the trajectories of cognitive decline in patients with LOEU. The present study aimed at assessing biomarkers of Alzheimer's disease (AD) in patients with LOEU and evaluating their cognitive performance for 12 months. For this study, 55 patients diagnosed with LOEU and 21 controls were included. Participants underwent cognitive evaluation and cerebrospinal fluid (CSF) biomarker analysis (ß-amyloid
Substances chimiques
tau Proteins
0
Amyloid beta-Peptides
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Biomarkers
0
Glucose
IY9XDZ35W2
Peptide Fragments
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5384-5396Informations de copyright
© 2022 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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