Amyloid, cerebrovascular disease, and neurodegeneration biomarkers are associated with cognitive trajectories in a racially and ethnically diverse, community-based sample.

Aged Aged, 80 and over Alzheimer Disease / diagnosis Amyloid Amyloidosis Biomarkers Cerebrovascular Disorders Cognition Cognitive Dysfunction / diagnosis Female Humans Infarction Magnetic Resonance Imaging Male Neuropsychological Tests Prospective Studies
Alzheimer's disease Cerebrovascular disease Cognitive decline Neuroimaging Race/Ethnicity

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
09 2022
Historique:
received: 19 10 2021
revised: 03 05 2022
accepted: 06 05 2022
pubmed: 10 6 2022
medline: 20 7 2022
entrez: 9 6 2022
Statut: ppublish

Résumé

We characterized the additive contribution of cerebrovascular biomarkers to amyloid and neurodegeneration biomarkers (AV(N)) when modeling prospective, longitudinal cognitive trajectories within 3 major racial/ethnic groups. Participants (n = 172; age = 69-96 years; 62% women; 31%/49%/20% Non-Hispanic White/Non-Hispanic Black/Hispanic) from the Washington Heights-Inwood Columbia Aging Project were assessed for amyloid (Florbetaben PET), neurodegeneration (cortical thickness, hippocampal volume), and cerebrovascular disease (white matter hyperintensity (WMH), infarcts). Neuropsychological assessments occurred every 2.3 ± 0.6 years for up to 6 visits (follow-up time: 4.2 ± 3.2 years). Linear mixed-effects models were stratified by race/ethnicity groups. Higher amyloid was associated with faster memory decline in all 3 racial/ethnic groups, but was related to faster cognitive decline beyond memory in minoritized racial/ethnic groups. Higher WMH was associated with faster language, processing speed/executive function, and visuospatial ability decline in Non-Hispanic Black participants, while infarcts were associated with faster processing speed/executive function decline in Non-Hispanic White participants. Complementary information from AD, neurodegenerative, and cerebrovascular biomarkers explain decline in multiple cognitive domains, which may differ within each racial/ethnic group. Importantly, treatment strategies exist to minimize vascular contributions to cognitive decline.

Identifiants

DOI: 10.1016/j.neurobiolaging.2022.05.004 PMID: 35679806 PMC: PMC9997572
pubmed: 35679806
pii: S0197-4580(22)00110-5
doi: 10.1016/j.neurobiolaging.2022.05.004
pmc: PMC9997572
mid: NIHMS1871390
pii:
doi:

Substances chimiques

Amyloid 0
Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

83-96

Subventions

Organisme : NIA NIH HHS
ID : R01 AG034189
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG034189
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054520
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG007232
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054023
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG037212
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG065506
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG072474
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

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Auteurs

Patrick J Lao (PJ)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Amelia K Boehme (AK)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Clarissa Morales (C)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Krystal K Laing (KK)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Anthony Chesebro (A)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Kay C Igwe (KC)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Jose Gutierrez (J)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Yian Gu (Y)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA.

Yaakov Stern (Y)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Nicole Schupf (N)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA.

Jennifer J Manly (JJ)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA.

Richard Mayeux (R)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Adam M Brickman (AM)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: amb2139@columbia.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Amyloïde › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Amyloïdose › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Amyloid, cerebrovascular disease, and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Amyloid, cerebrovascular disease, and...