Potential Anti-Inflammatory and Anti-Coagulation Effects of One-Time Application of Remote Ischemic Conditioning in Patients With Subacute/Chronic Cerebral Arteriostenosis and Venostenosis.
Journal
The neurologist
ISSN: 2331-2637
Titre abrégé: Neurologist
Pays: United States
ID NLM: 9503763
Informations de publication
Date de publication:
01 Nov 2022
01 Nov 2022
Historique:
pubmed:
10
6
2022
medline:
5
11
2022
entrez:
9
6
2022
Statut:
epublish
Résumé
Remote ischemic conditioning (RIC) is an extremely simple, non-invasive, and cost-effective method with a neuroprotective effect. This study aimed to evaluate the immediate effects of one-time application of RIC on inflammation and coagulation in patients with chronic cerebral vascular stenosis, and compare the different effects of RIC on cerebral arteriostenosis and cerebral venostenosis. A total of 47 patients with defined cerebral arteriostenosis (n=21) or venostenosis (n=26) were prospectively enrolled. RIC intervention was given once with 5 cycles of inflating and deflating for 5 minutes alternately. Blood was sampled 5 minutes before and after RIC for inflammatory and thrombophilia biomarkers. Differences in inflammatory and thrombotic variables at differing time points in the group were assessed using paired t tests or Wilcoxon matched-pairs signed-rank test. Patients with cerebral arteriostenosis had a higher level of pre-RIC neutrophil-to-lymphocyte ratio ( P =0.034), high-sensitivity C-reactive protein ( P =0.037), and fibrinogen ( P =0.002) than that with cerebral venostenosis. In the arterial group, levels of fibrinogen ( P =0.023) decreased, and interleukin-6 levels were elevated ( P =0.019) after a single RIC. Age was negatively related to interleukin-6, C-reactive protein, and fibrinogen. One-time RIC interventions may show seemingly coexisted proinflammatory and anti-coagulation effects of a single bout on patients with cerebral arteriostenosis. Older age was a negative predictor for multiple biomarkers in the cerebral arteriostensosis group. The protective effect of RIC on cerebral venostenosis patients needs to be further studied in a larger sample size.
Sections du résumé
BACKGROUND
BACKGROUND
Remote ischemic conditioning (RIC) is an extremely simple, non-invasive, and cost-effective method with a neuroprotective effect. This study aimed to evaluate the immediate effects of one-time application of RIC on inflammation and coagulation in patients with chronic cerebral vascular stenosis, and compare the different effects of RIC on cerebral arteriostenosis and cerebral venostenosis.
METHOD
METHODS
A total of 47 patients with defined cerebral arteriostenosis (n=21) or venostenosis (n=26) were prospectively enrolled. RIC intervention was given once with 5 cycles of inflating and deflating for 5 minutes alternately. Blood was sampled 5 minutes before and after RIC for inflammatory and thrombophilia biomarkers. Differences in inflammatory and thrombotic variables at differing time points in the group were assessed using paired t tests or Wilcoxon matched-pairs signed-rank test.
RESULTS
RESULTS
Patients with cerebral arteriostenosis had a higher level of pre-RIC neutrophil-to-lymphocyte ratio ( P =0.034), high-sensitivity C-reactive protein ( P =0.037), and fibrinogen ( P =0.002) than that with cerebral venostenosis. In the arterial group, levels of fibrinogen ( P =0.023) decreased, and interleukin-6 levels were elevated ( P =0.019) after a single RIC. Age was negatively related to interleukin-6, C-reactive protein, and fibrinogen.
CONCLUSION
CONCLUSIONS
One-time RIC interventions may show seemingly coexisted proinflammatory and anti-coagulation effects of a single bout on patients with cerebral arteriostenosis. Older age was a negative predictor for multiple biomarkers in the cerebral arteriostensosis group. The protective effect of RIC on cerebral venostenosis patients needs to be further studied in a larger sample size.
Identifiants
pubmed: 35680386
doi: 10.1097/NRL.0000000000000425
pii: 00127893-202211000-00006
pmc: PMC9631780
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
Interleukin-6
0
Biomarkers
0
Anti-Inflammatory Agents
0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
324-332Informations de copyright
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Crowley LE, McIntyre CW. Remote ischaemic conditioning-therapeutic opportunities in renal medicine. Nat Rev Nephrol. 2013;9:739–746.
Le Page S, Bejan-Angoulvant T, Angoulvant D, et al. Remote ischemic conditioning and cardioprotection: a systematic review and meta-analysis of randomized clinical trials. Basic Res Cardiol. 2015;110:11.
Heusch G, Gersh BJ. The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge. Eur Heart J. 2017;38:774–784.
Hess DC, Blauenfeldt RA, Andersen G, et al. Remote ischaemic conditioning-a new paradigm of self-protection in the brain. Nat Rev Neurol. 2015;11:698–710.
Landman TRJ, Schoon Y, Warlé MC, et al. Remote ischemic conditioning as an additional treatment for acute ischemic stroke. Stroke. 2019;50:1934–1939.
Loukogeorgakis SP, Panagiotidou AT, Broadhead MW, et al. Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans: role of the autonomic nervous system. J Am Coll Cardiol. 2005;46:450–456.
Heusch G, Bøtker HE, Przyklenk K, et al. Remote ischemic conditioning. J Am Coll Cardiol. 2015;65:177–195.
Küntscher MV, Juran S, Altmann J, et al. Role of nitric oxide in the mechanism of preclamping and remote ischemic preconditioning of adipocutaneous flaps in a rat model. J Reconstr Microsurg. 2003;19:55–60.
Küntscher MV, Kastell T, Altmann J, et al. Acute remote ischemic preconditioning ii: the role of nitric oxide. Microsurgery. 2002;22:227–231.
Zhao W, Che R, Li S, et al. Remote ischemic conditioning for acute stroke patients treated with thrombectomy. Ann Clin Transl Neurol. 2018;5:850–856.
Meng R, Ding Y, Asmaro K, et al. Ischemic conditioning is safe and effective for octo- and nonagenarians in stroke prevention and treatment. Neurotherapeutics. 2015;12:667–677.
Meng R, Asmaro K, Meng L, et al. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012;79:1853–1861.
Wang Y, Meng R, Song H, et al. Remote ischemic conditioning may improve outcomes of patients with cerebral small-vessel disease. Stroke. 2017;48:3064–3072.
Song S, Guo L, Wu D, et al. Quantitative proteomic analysis of plasma after remote ischemic conditioning in a rhesus monkey ischemic stroke model. Biomolecules. 2021;11:1164.
Zhao W, Zhang J, Sadowsky MG, et al. Remote ischaemic conditioning for preventing and treating ischaemic stroke. Cochrane Database Syst Rev. 2018;7:Cd012503.
Zhou D, Ding J, Ya J, et al. Remote ischemic conditioning: a promising therapeutic intervention for multi-organ protection. Aging (Albany NY). 2018;10:1825–1855.
Zhou G, Li MH, Tudor G, et al. Remote ischemic conditioning in cerebral diseases and neurointerventional procedures: recent research progress. Front Neurol. 2018;9:339.
Zhao W, Li S, Ren C, et al. Remote ischemic conditioning for stroke: clinical data, challenges, and future directions. Ann Clin Transl Neurol. 2019;6:186–196.
Hepponstall M, Ignjatovic V, Binos S, et al. Remote ischemic preconditioning (RIPC) modifies plasma proteome in humans. PLoS One. 2012;7:e48284.
Hibert P, Prunier-Mirebeau D, Beseme O, et al. Modifications in rat plasma proteome after remote ischemic preconditioning (RIPC) stimulus: identification by a seldi-tof-ms approach. PLoS One. 2014;9:e85669.
Ding J, Guan J, Rajah G, et al. Clinical and neuroimaging correlates among cohorts of cerebral arteriostenosis, venostenosis and arterio-venous stenosis. Aging (Albany NY). 2019;11:11073–11083.
Steinke W, Ries S, Artemis N, et al. Power doppler imaging of carotid artery stenosis. Comparison with color doppler flow imaging and angiography. Stroke. 1997;28:1981–1987.
Zivadinov R, Bastianello S, Dake MD, et al. Recommendations for multimodal noninvasive and invasive screening for detection of extracranial venous abnormalities indicative of chronic cerebrospinal venous insufficiency: a position statement of the international society for neurovascular disease. J Vasc Interv Radiol. 2014;25:1785–1794.e1717.
Zamboni P, Morovic S, Menegatti E, et al. Screening for chronic cerebrospinal venous insufficiency (CCSVI) using ultrasound--recommendations for a protocol. Int Angiol. 2011;30:571–597.
Saposnik G, Barinagarrementeria F, Brown RD Jr, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:1158–1192.
Ferro JM, Bousser MG, Canhão P, et al. European stroke organization guideline for the diagnosis and treatment of cerebral venous thrombosis—endorsed by the European Academy of Neurology. Eur J Neurol. 2017;24:1203–1213.
Yang J, Balkaya M, Beltran C, et al. Remote postischemic conditioning promotes stroke recovery by shifting circulating monocytes to CCR2(+) proinflammatory subset. J Neurosci. 2019;39:7778–7789.
Vaibhav K, Braun M, Khan MB, et al. Remote ischemic post-conditioning promotes hematoma resolution via AMPK-dependent immune regulation. J Exp Med. 2018;215:2636–2654.
Soysal P, Stubbs B, Lucato P, et al. Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Res Rev. 2016;31:1–8.
Muller J, Taebling M, Oberhoffer R. Remote ischemic preconditioning has no short term effect on blood pressure, heart rate, and arterial stiffness in healthy young adults. Front Physiol. 2019;10:1094.
Sogorski A, Spindler S, Wallner C, et al. Optimizing remote ischemic conditioning (RIC) of cutaneous microcirculation in humans: number of cycles and duration of acute effects. J Plast Reconstr Aesthet Surg. 2021;74:819–827.
Kraemer R, Lorenzen J, Kabbani M, et al. Acute effects of remote ischemic preconditioning on cutaneous microcirculation—a controlled prospective cohort study. BMC Surg. 2011;11:32.