Use of hypnotics among women diagnosed with cervical cancer - A population-based cohort study.


Journal

Gynecologic oncology
ISSN: 1095-6859
Titre abrégé: Gynecol Oncol
Pays: United States
ID NLM: 0365304

Informations de publication

Date de publication:
08 2022
Historique:
received: 03 03 2022
revised: 18 05 2022
accepted: 23 05 2022
pubmed: 10 6 2022
medline: 29 7 2022
entrez: 9 6 2022
Statut: ppublish

Résumé

Previous studies suggest that sleeping problems are frequent after cervical cancer. However, the evidence on the use of hypnotics is sparse. We investigated if women diagnosed with cervical cancer have an increased risk of using hypnotics and identified risk factors for prolonged use. In this nationwide register-based cohort study, 4264 women diagnosed with cervical cancer from 1997 to 2013 and 36,632 cancer-free women were followed in registers until 2016. Prolonged use of hypnotics was defined as more than three prescriptions with no more than three months in between. Data were analysed using Cox proportional hazards regression models and multistate Markov models separately for women with localized and advanced cervical cancer. The rate of first use of hypnotics was substantially increased during the first year after cervical cancer diagnosis compared to cancer-free women (HR Women diagnosed with cervical cancer are at increased risk of prolonged use of hypnotics. For the majority, treatment with hypnotics is initiated within the first year after cancer diagnosis, but the rate of first use is increased for up to five years.

Identifiants

pubmed: 35680430
pii: S0090-8258(22)00330-4
doi: 10.1016/j.ygyno.2022.05.019
pii:
doi:

Substances chimiques

Anti-Anxiety Agents 0
Antidepressive Agents 0
Hypnotics and Sedatives 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

300-307

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None declared.

Auteurs

Trine Allerslev Horsbøl (TA)

National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark; Survivorship and Inequality in Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark. Electronic address: tria@sdu.dk.

Susanne K Kjaer (SK)

Department of Gynaecology, Copenhagen University Hospital, Copenhagen, Denmark; Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Elisabeth Wreford Andersen (EW)

Statistics and Data Analysis, Danish Cancer Society Research Center, Copenhagen, Denmark.

Gunn Ammitzbøll (G)

Survivorship and Inequality in Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark; Danish Research Center for Equality in Cancer (COMPAS), Department of Clinical Oncology & Palliative Care, Zealand University Hospital, Næstved, Denmark.

Lau Caspar Thygesen (LC)

National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.

Christoffer Johansen (C)

Survivorship and Inequality in Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark; Late Effect Research Unit CASTLE, Copenhagen University Hospital, Copenhagen, Denmark.

Pernille Tine Jensen (PT)

Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

Ligita Paskeviciute Frøding (LP)

Department of Gynaecology, Copenhagen University Hospital, Copenhagen, Denmark.

Henrik Lajer (H)

Department of Gynaecology, Copenhagen University Hospital, Copenhagen, Denmark.

Susanne Oksbjerg Dalton (SO)

Survivorship and Inequality in Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark; Danish Research Center for Equality in Cancer (COMPAS), Department of Clinical Oncology & Palliative Care, Zealand University Hospital, Næstved, Denmark.

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Classifications MeSH