Efferocytosis requires periphagosomal Ca


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
09 06 2022
Historique:
received: 22 07 2019
accepted: 26 05 2022
entrez: 10 6 2022
pubmed: 11 6 2022
medline: 14 6 2022
Statut: epublish

Résumé

Efficient clearance of apoptotic cells by phagocytosis, also known as efferocytosis, is fundamental to developmental biology, organ physiology, and immunology. Macrophages use multiple mechanisms to detect and engulf apoptotic cells, but the signaling pathways that regulate the digestion of the apoptotic cell cargo, such as the dynamic Ca

Identifiants

pubmed: 35680919
doi: 10.1038/s41467-022-30959-4
pii: 10.1038/s41467-022-30959-4
pmc: PMC9184625
doi:

Substances chimiques

TRPM Cation Channels 0
Trpm7 protein, mouse EC 2.7.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

3230

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI155808
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM108989
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007055
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007267
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Michael S Schappe (MS)

Pharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.
Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

Marta E Stremska (ME)

Pharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.

Gregory W Busey (GW)

Pharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.

Taylor K Downs (TK)

Pharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.

Philip V Seegren (PV)

Pharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.

Suresh K Mendu (SK)

Pharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.

Zachary Flegal (Z)

Pharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.

Catherine A Doyle (CA)

Pharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.

Eric J Stipes (EJ)

Pharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.

Bimal N Desai (BN)

Pharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA. bdesai@virginia.edu.
Carter Immunology Center, University of Virginia, 345 Crispell Dr. MR-6, Charlottesville, VA, 22908, USA. bdesai@virginia.edu.
Robert M. Berne Cardiovascular Research Center, University of Virginia, 415 Lane Rd, Charlottesville, VA, 22908, USA. bdesai@virginia.edu.

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