Distinct dissociation rates of murine and human norovirus P-domain dimers suggest a role of dimer stability in virus-host interactions.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
09 06 2022
09 06 2022
Historique:
received:
19
03
2021
accepted:
19
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
Norovirus capsids are icosahedral particles composed of 90 dimers of the major capsid protein VP1. The C-terminus of the VP1 proteins forms a protruding (P)-domain, mediating receptor attachment, and providing a target for neutralizing antibodies. NMR and native mass spectrometry directly detect P-domain monomers in solution for murine (MNV) but not for human norovirus (HuNoV). We report that the binding of glycochenodeoxycholic acid (GCDCA) stabilizes MNV-1 P-domain dimers (P-dimers) and induces long-range NMR chemical shift perturbations (CSPs) within loops involved in antibody and receptor binding, likely reflecting corresponding conformational changes. Global line shape analysis of monomer and dimer cross-peaks in concentration-dependent methyl TROSY NMR spectra yields a dissociation rate constant k
Identifiants
pubmed: 35680964
doi: 10.1038/s42003-022-03497-4
pii: 10.1038/s42003-022-03497-4
pmc: PMC9184547
doi:
Substances chimiques
Capsid Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
563Subventions
Organisme : NIAID NIH HHS
ID : R01 AI141465
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
mSphere. 2017 Oct 18;2(5):
pubmed: 29062895
J Med Chem. 2019 Sep 12;62(17):8274-8283
pubmed: 31393717
Chembiochem. 2020 Apr 1;21(7):1007-1021
pubmed: 31644826
J Virol. 2015 Feb;89(4):2024-40
pubmed: 25428879
Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12014-9
pubmed: 26329854
J Am Chem Soc. 2010 Jun 9;132(22):7589-91
pubmed: 20465253
J Virol. 2021 Oct 27;95(22):e0147121
pubmed: 34468172
Proteins. 2005 Jun 1;59(4):687-96
pubmed: 15815974
Biomol NMR Assign. 2022 Apr;16(1):97-107
pubmed: 35050443
Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12828-12832
pubmed: 31182604
PLoS Pathog. 2020 Apr 6;16(4):e1008242
pubmed: 32251490
PLoS Pathog. 2020 Jul 2;16(7):e1008619
pubmed: 32614892
J Virol. 2010 Jun;84(11):5695-705
pubmed: 20335262
J Mol Biol. 2002 Mar 1;316(4):875-85
pubmed: 11884128
Prog Nucl Magn Reson Spectrosc. 2020 Feb;116:56-84
pubmed: 32130959
J Am Chem Soc. 2011 Jun 1;133(21):8272-81
pubmed: 21545099
Nat Protoc. 2006;1(2):749-54
pubmed: 17406304
J Pharm Pharmacol. 2008 Jan;60(1):63-70
pubmed: 18088506
Lancet Infect Dis. 2018 May;18(5):545-553
pubmed: 29396001
J Biomol NMR. 2019 Apr;73(3-4):191-198
pubmed: 31041649
Structure. 1999 Jul 15;7(7):853-64
pubmed: 10425686
J Chromatogr A. 2006 Nov 3;1132(1-2):99-108
pubmed: 16887127
Science. 2016 Aug 26;353(6302):933-6
pubmed: 27540007
J Biomol NMR. 2004 Feb;28(2):165-72
pubmed: 14755160
J Biomol NMR. 2010 Sep;48(1):31-47
pubmed: 20734113
Curr Protoc Microbiol. 2014 May 01;33:15K.2.1-61
pubmed: 24789596
Virus Res. 2009 Jul;143(1):125-9
pubmed: 19463729
J Virol. 2010 Jun;84(11):5836-41
pubmed: 20335264
J Virol. 2019 Jan 4;93(2):
pubmed: 30355683
PLoS Biol. 2004 Dec;2(12):e432
pubmed: 15562321
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2140-5
pubmed: 24469799
Science. 1999 Oct 8;286(5438):287-90
pubmed: 10514371
J Am Chem Soc. 2010 Dec 29;132(51):18340-50
pubmed: 21138300
Prog Nucl Magn Reson Spectrosc. 2013 Aug;73:1-16
pubmed: 23962882
Prog Nucl Magn Reson Spectrosc. 2014 Apr;78:47-75
pubmed: 24534088
Molecules. 2021 Apr 07;26(8):
pubmed: 33917179
PLoS Biol. 2020 Mar 31;18(3):e3000649
pubmed: 32231352
J Biomol NMR. 2020 Jan;74(1):95-109
pubmed: 31915980
Prog Nucl Magn Reson Spectrosc. 2014 Jul;80:26-63
pubmed: 24924266
BMC Biotechnol. 2008 Dec 04;8:91
pubmed: 19055817
Top Curr Chem. 2013;335:97-119
pubmed: 21928013
J Biomol NMR. 1995 Nov;6(3):277-93
pubmed: 8520220
Viruses. 2019 Mar 08;11(3):
pubmed: 30857192
mBio. 2013 Jul 16;4(4):
pubmed: 23860770
Science. 2014 Nov 7;346(6210):755-9
pubmed: 25378626
J Biomol NMR. 2012 Jul;53(3):209-21
pubmed: 22689066
Protein Sci. 2021 Jan;30(1):70-82
pubmed: 32881101
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6248-E6255
pubmed: 27681626
J Virol Methods. 2010 Oct;169(1):112-8
pubmed: 20637238
J Am Chem Soc. 2007 Oct 24;129(42):12668-9
pubmed: 17910459
Angew Chem Int Ed Engl. 2019 Jun 24;58(26):8784-8788
pubmed: 30997945
Biomol NMR Assign. 2020 Apr;14(1):123-130
pubmed: 31993958
Nat Rev Microbiol. 2016 Jul;14(7):421-33
pubmed: 27211790
J Biomol NMR. 2017 Jul;68(3):225-236
pubmed: 28653216
Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9201-E9210
pubmed: 30194229
Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1700-1710
pubmed: 31896578
Viruses. 2020 Sep 05;12(9):
pubmed: 32899556
J Virol. 2021 Jun 10;95(13):e0017621
pubmed: 33827952
Nat Commun. 2019 Mar 21;10(1):1320
pubmed: 30899001
J Chem Inf Model. 2021 Dec 27;61(12):5726-5733
pubmed: 34843238
Elife. 2015 Jul 20;4:e07454
pubmed: 26193119
J Biol Chem. 2013 May 3;288(18):12533-43
pubmed: 23482561
J Biol Chem. 1998 Jan 9;273(2):1223-31
pubmed: 9422790
Chembiochem. 2009 Jun 15;10(9):1477-9
pubmed: 19466705
Science. 2016 Sep 23;353(6306):1387-1393
pubmed: 27562956
J Gen Virol. 2014 Sep;95(Pt 9):1958-1968
pubmed: 24899153
J Gen Virol. 2014 Feb;95(Pt 2):413-422
pubmed: 24225497
J Virol. 2008 Mar;82(5):2079-88
pubmed: 18094184
Bioinformatics. 2016 Dec 1;32(23):3676-3678
pubmed: 27503228
Chem Rev. 2016 Jun 8;116(11):6323-69
pubmed: 26734986
Sci Rep. 2019 Feb 25;9(1):2650
pubmed: 30804351
J Virol. 2019 Sep 12;93(19):
pubmed: 31341042
Chem Commun (Camb). 2019 Dec 7;55(94):14107-14110
pubmed: 31642826
J Am Chem Soc. 2003 Aug 27;125(34):10420-8
pubmed: 12926967
Protein Sci. 2018 Jan;27(1):14-25
pubmed: 28710774
PLoS Med. 2015 Dec 03;12(12):e1001921
pubmed: 26633831
Sci Rep. 2016 Apr 25;6:24826
pubmed: 27109776
J Virol. 2018 May 14;92(11):
pubmed: 29563286