Does race-ethnicity affect upper airway stimulation adherence and treatment outcome of obstructive sleep apnea?
Epworth Sleepiness Scale
adherence
apnea-hypopnea index
health care disparities
hypoglossal nerve stimulation
obstructive sleep apnea
positive airway therapy
upper airway stimulation
Journal
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
ISSN: 1550-9397
Titre abrégé: J Clin Sleep Med
Pays: United States
ID NLM: 101231977
Informations de publication
Date de publication:
01 09 2022
01 09 2022
Historique:
pubmed:
11
6
2022
medline:
9
9
2022
entrez:
10
6
2022
Statut:
ppublish
Résumé
Untreated obstructive sleep apnea (OSA) is associated with excessive daytime sleepiness, decreased quality of life, and cardiovascular disease. Positive airway pressure is the first-line therapy for OSA; however, adherence is difficult. Upper airway stimulation is a Food and Drug Administration-approved treatment of OSA. The objective of this study was to evaluate for a difference in treatment efficacy and adherence of upper airway stimulation therapy for OSA between individuals who are White and non-White using data from the ADHERE registry. ADHERE registry is a multicenter prospective study of real-world experience of upper airway stimulation for treatment of OSA in the United States and Europe. Propensity score matching was used to create a balanced dataset between the White and non-White groups. There were 2,755 participants of the ADHERE registry: 27 were excluded due to not having a race identified, 125 participants identified as non-White, 2,603 identify as White, and 27 did not provide race information. Propensity score matching was used to select 110 participants, with 55 White and 55 non-White for the noninferiority analysis. We did not find a difference in adherence, treatment apnea-hypopnea index, changes in Epworth Sleepiness Scale score, or clinical global impression after intervention score between White and non-White individuals. Our study found that there was no statistically significant difference in adherence or efficacy with upper airway stimulation therapy between White and non-White individuals. However, the percent of non-White people implanted is low, which suggests a need to expand access to this therapy for non-White populations with OSA who cannot tolerate positive airway pressure therapy. Khan M, Stone A, Soose RJ, et al. Does race-ethnicity affect upper airway stimulation adherence and treatment outcome of obstructive sleep apnea?
Identifiants
pubmed: 35681251
pii: jcsm.10068
doi: 10.5664/jcsm.10068
pmc: PMC9435342
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2167-2172Subventions
Organisme : NHLBI NIH HHS
ID : U01 HL125177
Pays : United States
Organisme : NHLBI NIH HHS
ID : UH3 HL140144
Pays : United States
Informations de copyright
© 2022 American Academy of Sleep Medicine.
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