Pancreatic Ductal Adenocarcinoma: Current and Emerging Therapeutic Uses of Focused Ultrasound.
HIFU
PDAC
cavitation
drug delivery
focused ultrasound
immunotherapy
sonodynamic therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
24 May 2022
24 May 2022
Historique:
received:
31
03
2022
revised:
13
05
2022
accepted:
16
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
11
6
2022
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) diagnosis accompanies a somber prognosis for the patient, with dismal survival odds: 5% at 5 years. Despite extensive research, PDAC is expected to become the second leading cause of mortality by cancer by 2030. Ultrasound (US) has been used successfully in treating other types of cancer and evidence is flourishing that it could benefit PDAC patients. High-intensity focused US (HIFU) is currently used for pain management in palliative care. In addition, clinical work is being performed to use US to downstage borderline resectable tumors and increase the proportion of patients eligible for surgical ablation. Focused US (FUS) can also induce mechanical effects, which may elicit an anti-tumor response through disruption of the stroma and can be used for targeted drug delivery. More recently, sonodynamic therapy (akin to photodynamic therapy) and immunomodulation have brought new perspectives in treating PDAC. The aim of this review is to summarize the current state of those techniques and share our opinion on their future and challenges.
Identifiants
pubmed: 35681557
pii: cancers14112577
doi: 10.3390/cancers14112577
pmc: PMC9179649
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Agence Nationale de la Recherche
ID : PCSI 2020 Call
Organisme : ITMO
ID : Cancer
Références
Int J Hyperthermia. 2018 May;34(3):284-291
pubmed: 28715967
J Acoust Soc Am. 1990 Nov;88(5):2059-69
pubmed: 2269722
Expert Rev Anticancer Ther. 2007 Jun;7(6):823-31
pubmed: 17555392
Br J Surg. 2010 Feb;97(2):220-5
pubmed: 20069610
Ultrasound Med Biol. 2019 May;45(5):1056-1080
pubmed: 30922619
Ultrasound Med Biol. 2016 Feb;42(2):518-27
pubmed: 26547633
Ultrason Sonochem. 2015 Nov;27:694-702
pubmed: 26113389
Ultrasound Med Biol. 1991;17(2):179-85
pubmed: 2053214
N Engl J Med. 2014 Sep 11;371(11):1039-49
pubmed: 25207767
Cancers (Basel). 2021 Apr 20;13(8):
pubmed: 33923884
IEEE Trans Ultrason Ferroelectr Freq Control. 2017 Jan;64(1):177-191
pubmed: 27992331
Eur Radiol. 2016 Nov;26(11):4047-4056
pubmed: 26886904
Cancer Cell. 2014 Jun 16;25(6):719-34
pubmed: 24856586
Int J Hyperthermia. 2015 Mar;31(2):145-62
pubmed: 25707817
J Acoust Soc Am. 2011 Oct;130(4):1888-98
pubmed: 21973343
J Gastroenterol Hepatol. 2017 Feb;32(2):439-445
pubmed: 27356212
Oper Neurosurg (Hagerstown). 2020 Jul 1;19(1):9-18
pubmed: 31853548
Onco Targets Ther. 2019 Feb 01;12:1021-1029
pubmed: 30774386
Int J Hyperthermia. 2012;28(1):69-86
pubmed: 22235787
Sci Rep. 2019 Oct 30;9(1):15581
pubmed: 31666639
Cancers (Basel). 2021 Dec 20;13(24):
pubmed: 34945001
IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Jul;65(7):1093-1101
pubmed: 29985133
Eur J Pharm Biopharm. 2021 Jun;163:49-59
pubmed: 33798727
Clin Res Hepatol Gastroenterol. 2019 Nov;43(6):669-681
pubmed: 31031131
Phys Med Biol. 2013 Jul 21;58(14):4981-5005
pubmed: 23807573
Ann Gastroenterol Surg. 2020 Aug 09;5(1):7-23
pubmed: 33532676
Cancer Cell. 2014 Jun 16;25(6):735-47
pubmed: 24856585
J Control Release. 2018 Jun 10;279:8-16
pubmed: 29653222
Ultrasound Med Biol. 2020 Jun;46(6):1296-1325
pubmed: 32165014
World J Gastroenterol. 2014 Jul 28;20(28):9570-7
pubmed: 25071354
Cancers (Basel). 2022 Jan 27;14(3):
pubmed: 35158903
J Acoust Soc Am. 2009 Dec;126(6):3071-83
pubmed: 20000921
Phys Med Biol. 2018 Dec 04;63(23):235023
pubmed: 30511651
J Control Release. 2020 Jan 10;317:23-33
pubmed: 31733295
Ultrasound Med Biol. 2013 Mar;39(3):449-65
pubmed: 23380152
Sci Rep. 2019 Dec 12;9(1):18916
pubmed: 31831785
World J Clin Oncol. 2011 Jan 10;2(1):8-27
pubmed: 21603311
Phys Med Biol. 2012 Dec 7;57(23):8061-78
pubmed: 23159812
Ultrasound Med Biol. 2010 Feb;36(2):250-67
pubmed: 20018433
IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Feb;65(2):258-268
pubmed: 29389657
Chin Med J (Engl). 2002 Sep;115(9):1332-5
pubmed: 12411106
Ultrasound Med Biol. 2006 Jan;32(1):115-29
pubmed: 16364803
Chem Commun (Camb). 2021 Mar 18;57(23):2854-2866
pubmed: 33625416
J Control Release. 2006 May 15;112(2):149-55
pubmed: 16556469
Neurosurg Focus. 2020 Jan 1;48(1):E10
pubmed: 31896084
Pancreas. 2017 Feb;46(2):219-224
pubmed: 27841792
Endosc Ultrasound. 2020 Mar-Apr;9(2):83-100
pubmed: 32295966
Br J Surg. 2015 Feb;102(3):182-93
pubmed: 25524417
Opt Express. 2007 Jul 9;15(14):8931-7
pubmed: 19547231
Ultrasound Med Biol. 2017 Oct;43(10):2295-2301
pubmed: 28705555
BMC Cancer. 2020 Mar 12;20(1):203
pubmed: 32164564
Ultrason Sonochem. 2015 Nov;27:703-706
pubmed: 26044461
Int Rev Immunol. 2017 Nov 2;36(6):338-351
pubmed: 28961038
Biomaterials. 2016 Feb;80:20-32
pubmed: 26702983
IEEE Trans Ultrason Ferroelectr Freq Control. 2021 Nov;68(11):3336-3346
pubmed: 34166187
Int J Hyperthermia. 2021 Sep;38(2):65-74
pubmed: 34420445
Int J Hyperthermia. 2005 Dec;21(8):745-53
pubmed: 16338857
Eur J Surg Oncol. 2020 Aug;46(8):1510-1515
pubmed: 32146053
Cancer Res. 2014 Jun 1;74(11):2913-21
pubmed: 24840647
J Exp Med. 2014 May 5;211(5):781-90
pubmed: 24778419
Cardiovasc Intervent Radiol. 2011 Apr;34(2):419-23
pubmed: 20521049
Eur Radiol. 2021 Aug;31(8):5818-5829
pubmed: 33486605
Ultrasound Med Biol. 2020 Nov;46(11):3046-3058
pubmed: 32829983
Phys Med Biol. 2005 Oct 21;50(20):4797-809
pubmed: 16204873
J Control Release. 2017 Sep 28;262:192-200
pubmed: 28764995
IEEE Trans Ultrason Ferroelectr Freq Control. 2004 Jun;51(6):726-36
pubmed: 15244286
Mol Ther. 2010 Jan;18(1):101-8
pubmed: 19623162
J Acoust Soc Am. 2013 Aug;134(2):1695-701
pubmed: 23927210
Rofo. 2016 Jul;188(7):662-70
pubmed: 27272685
J Control Release. 2021 Sep 10;337:371-377
pubmed: 34274382
Gut Liver. 2010 Sep;4 Suppl 1:S57-61
pubmed: 21103296
Medicine (Baltimore). 2020 Feb;99(6):e19099
pubmed: 32028435
IEEE Trans Med Imaging. 2018 Jan;37(1):106-115
pubmed: 28783627
Oncotarget. 2015 Aug 21;6(24):20241-51
pubmed: 26036312
Schmerz. 2017 Feb;31(1):31-39
pubmed: 27402264
Radiology. 2011 Apr;259(1):39-56
pubmed: 21436096
Br J Cancer. 2021 Jun;124(12):1941-1948
pubmed: 33772154
IEEE Trans Biomed Eng. 2014 Apr;61(4):1285-94
pubmed: 24658252
J Clin Med. 2020 Feb 07;9(2):
pubmed: 32046072
Anticancer Res. 2005 Mar-Apr;25(2B):1225-35
pubmed: 15865070
Biochem Biophys Res Commun. 2008 Oct 31;375(4):645-50
pubmed: 18727919
Jpn J Cancer Res. 1990 Sep;81(9):962-6
pubmed: 2172198
Ultraschall Med. 2018 Dec;39(6):650-658
pubmed: 29346805
J Control Release. 2010 Dec 20;148(3):368-72
pubmed: 20868711
Cancer Lett. 2021 Oct 1;517:88-95
pubmed: 34119606
Eur J Surg Oncol. 2019 May;45(5):788-792
pubmed: 30527222
J R Soc Interface. 2021 Jul;18(180):20210266
pubmed: 34229458
Proc Inst Mech Eng H. 2010;224(2):343-61
pubmed: 20349823
Thorax. 2004 Sep;59(9):790-3
pubmed: 15333857
Sci Rep. 2017 Jan 19;7:40967
pubmed: 28102324
Ultrasound Med Biol. 2021 Mar;47(3):693-709
pubmed: 33349516
Curr Cancer Drug Targets. 2015;15(4):282-313
pubmed: 25760762
J Ultrasound Med. 2019 Mar;38(3):567-580
pubmed: 30338863
Int J Hyperthermia. 2018;35(1):398-418
pubmed: 30428728
Hepatobiliary Surg Nutr. 2016 Aug;5(4):329-44
pubmed: 27500145
Biochem Biophys Res Commun. 2005 Sep 16;335(1):124-31
pubmed: 16055092
JOP. 2015 Jan 31;16(1):66-9
pubmed: 25640787
Sci Rep. 2018 May 10;8(1):7472
pubmed: 29748624
Acta Biomater. 2021 Jul 15;129:269-279
pubmed: 34082101
Ecancermedicalscience. 2016 Apr 21;10:635
pubmed: 27170835
Cancer Res. 2014 Feb 1;74(3):665-74
pubmed: 24336068
Cancers (Basel). 2019 Jul 12;11(7):
pubmed: 31336859
Int J Hyperthermia. 2021;38(1):561-575
pubmed: 33827375
Ultraschall Med. 2019 Oct;40(5):625-637
pubmed: 29665583
J Control Release. 2016 Dec 10;243:172-181
pubmed: 27744037
IEEE Trans Med Imaging. 2017 Apr;36(4):983-993
pubmed: 28026755
Ultrasonics. 2014 Dec;54(8):2151-8
pubmed: 25015000
IEEE Trans Ultrason Ferroelectr Freq Control. 2021 Sep;68(9):2987-3000
pubmed: 33956631
Ultrasound Med Biol. 1975 Mar;1(4):369-76
pubmed: 1098249
Cancer Res. 2015 Sep 15;75(18):3738-46
pubmed: 26216548
PLoS One. 2013 Nov 01;8(11):e76260
pubmed: 24223700
IEEE Trans Ultrason Ferroelectr Freq Control. 2016 May 10;63(8):1064-1077
pubmed: 28113706
J Ther Ultrasound. 2017 Apr 1;5:9
pubmed: 28373906
Phys Med Biol. 2016 Jul 21;61(14):5253-74
pubmed: 27353199
J Control Release. 2015 Apr 10;203:51-6
pubmed: 25660073
Mol Pharm. 2017 Feb 6;14(2):441-447
pubmed: 28107023
Pancreatology. 2013 Nov-Dec;13(6):634-8
pubmed: 24280584
Discov Med. 2016 Jun;21(118):435-45
pubmed: 27448780