Tumor Necrosis Factor Receptor 2 (TNFR2): An Emerging Target in Cancer Therapy.
NFkappaB
TNF receptor 2 (TNFR2)
TNF receptor associated factor 1 and 2 (TRAF1, TRAF2)
regulatory T-cell (Treg)
tumor necrosis factor (TNF)
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
25 May 2022
25 May 2022
Historique:
received:
18
04
2022
revised:
19
05
2022
accepted:
22
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
11
6
2022
Statut:
epublish
Résumé
Despite the great success of TNF blockers in the treatment of autoimmune diseases and the identification of TNF as a factor that influences the development of tumors in many ways, the role of TNFR2 in tumor biology and its potential suitability as a therapeutic target in cancer therapy have long been underestimated. This has been fundamentally changed with the identification of TNFR2 as a regulatory T-cell (Treg)-stimulating factor and the general clinical breakthrough of immunotherapeutic approaches. However, considering TNFR2 as a sole immunosuppressive factor in the tumor microenvironment does not go far enough. TNFR2 can also co-stimulate CD8
Identifiants
pubmed: 35681583
pii: cancers14112603
doi: 10.3390/cancers14112603
pmc: PMC9179537
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : project number 324392634 - TRR 221
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG WA 1025/33-1
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