Timeline of FDA-Approved Targeted Therapy for Cholangiocarcinoma.

CCA FDA biliary cancer cholangiocarcinoma targeted therapy

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
26 May 2022
Historique:
received: 18 04 2022
revised: 19 05 2022
accepted: 24 05 2022
entrez: 10 6 2022
pubmed: 11 6 2022
medline: 11 6 2022
Statut: epublish

Résumé

Cholangiocarcinoma (CCA) represents approximately 3% of gastrointestinal malignancies worldwide and constitutes around 10-15% of all primary liver cancers, being only second to hepatocellular carcinoma. Mortality from CCA has been on the rise in recent decades, and in the United States alone there has been a 36% increase in CCA from 1999 to 2014, with over 7000 CCA mortalities since 2013. Targeted therapies, which have been gaining interest due to their greater specificity toward cancer cells, have only recently started gaining FDA approval for the treatment of CCA. In this manuscript, we will go through the timeline of current FDA-approved targeted therapies as well as those that have gained FDA breakthrough therapy designation.

Identifiants

pubmed: 35681621
pii: cancers14112641
doi: 10.3390/cancers14112641
pmc: PMC9179455
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Su Min Cho (SM)

Department of Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Department of Medicine, Texas A&M College of Medicine, Bryan, TX 77807, USA.

Abdullah Esmail (A)

Section of GI Oncology, Department of Medical Oncology, Houston Methodist Cancer Center, Houston, TX 77030, USA.

Ali Raza (A)

Department of Gastroenterology, Houston Methodist Hospital, Houston, TX 77030, USA.

Sunil Dacha (S)

Department of Gastroenterology, Houston Methodist Hospital, Houston, TX 77030, USA.

Maen Abdelrahim (M)

Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Section of GI Oncology, Department of Medical Oncology, Houston Methodist Cancer Center, Houston, TX 77030, USA.
Cockrell Center of Advanced Therapeutics Phase I Program, Houston Methodist Research Institute, Houston, TX 77030, USA.

Classifications MeSH