Toxicity and Clinical Results after Proton Therapy for Pediatric Medulloblastoma: A Multi-Centric Retrospective Study.
medulloblastoma
pediatric brain tumors
proton therapy
radiation
toxicity
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
01 Jun 2022
01 Jun 2022
Historique:
received:
17
05
2022
revised:
28
05
2022
accepted:
30
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
11
6
2022
Statut:
epublish
Résumé
Medulloblastoma is the most common malignant brain tumor in children. Even if current treatment dramatically improves the prognosis, survivors often develop long-term treatment-related sequelae. The current radiotherapy standard for medulloblastoma is craniospinal irradiation with a boost to the primary tumor site and to any metastatic sites. Proton therapy (PT) has similar efficacy compared to traditional photon-based radiotherapy but might achieve lower toxicity rates. We report on our multi-centric experience with 43 children with medulloblastoma (median age at diagnosis 8.7 years, IQR 6.6, M/F 23/20; 26 high-risk, 14 standard-risk, 3 ex-infant), who received active scanning PT between 2015 and 2021, with a focus on PT-related acute-subacute toxicity, as well as some preliminary data on late toxicity. Most acute toxicities were mild and manageable with supportive therapy. Hematological toxicity was limited, even among HR patients who underwent hematopoietic stem-cell transplantation before PT. Preliminary data on late sequelae were also encouraging, although a longer follow-up is needed.
Identifiants
pubmed: 35681727
pii: cancers14112747
doi: 10.3390/cancers14112747
pmc: PMC9179586
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Int J Radiat Oncol Biol Phys. 2021 Mar 1;109(3):726-735
pubmed: 33243479
J Neurol Sci. 2017 Jan 15;372:413-416
pubmed: 27856004
Radiother Oncol. 2019 Mar;132:155-161
pubmed: 30414759
J Neurooncol. 2009 Nov;95(2):271-279
pubmed: 19521664
Int J Radiat Oncol Biol Phys. 2018 Dec 1;102(5):1465-1471
pubmed: 30092336
Radiother Oncol. 2010 Apr;95(1):23-31
pubmed: 19581014
J Clin Oncol. 1993 Jun;11(6):1033-8
pubmed: 8501489
J Pediatr Hematol Oncol. 2013 Aug;35(6):462-7
pubmed: 23892352
J Clin Oncol. 2014 Jun 10;32(17):1760-8
pubmed: 24516024
Hippocampus. 2017 Nov;27(11):1140-1154
pubmed: 28667671
Acta Oncol. 2014 Sep;53(9):1158-64
pubmed: 24913151
Phys Med. 2019 Apr;60:168-173
pubmed: 31000079
J Neurooncol. 2014 Apr;117(2):311-20
pubmed: 24515423
J Clin Oncol. 2017 Jul 20;35(21):2355-2363
pubmed: 28640708
Pediatr Blood Cancer. 2017 Dec;64(12):
pubmed: 28544746
J Med Ethics. 2014 Aug;40(8):572-5
pubmed: 24045770
Radiother Oncol. 2018 Jul;128(1):128-132
pubmed: 29373195
BMJ. 2012 Sep 05;345:e4917
pubmed: 22951923
Neurochirurgie. 2021 Feb;67(1):83-86
pubmed: 30149928
Radiat Oncol. 2013 Jul 23;8(1):184
pubmed: 23880421
Neuro Oncol. 2017 May 1;19(5):689-698
pubmed: 28039368
J Clin Oncol. 2018 Oct 1;36(28):2854-2862
pubmed: 30118397
Clin Oncol (R Coll Radiol). 2019 Mar;31(3):171-181
pubmed: 30655168
Nat Rev Dis Primers. 2019 Feb 14;5(1):11
pubmed: 30765705
Pediatr Neurol. 2015 Sep;53(3):211-5
pubmed: 26302700
Radiother Oncol. 2001 Sep;60(3):267-72
pubmed: 11514006
Horm Res Paediatr. 2019;91(2):74-82
pubmed: 30404091
Int J Radiat Oncol Biol Phys. 2008 Apr 1;70(5):1336-42
pubmed: 18029111
Int J Radiat Oncol Biol Phys. 2013 Jun 1;86(2):277-84
pubmed: 23433794
Lancet Oncol. 2017 Feb;18(2):e91-e100
pubmed: 28214420
Neuro Oncol. 2017 Oct 01;19(10):1408-1418
pubmed: 28541578
Lancet Oncol. 2016 Mar;17(3):287-298
pubmed: 26830377
Neurologist. 2016 Nov;21(6):112-117
pubmed: 27801773
Int J Radiat Oncol Biol Phys. 2002 Mar 15;52(4):1008-16
pubmed: 11958896
Cancer. 2005 Feb 15;103(4):793-801
pubmed: 15637691
Pediatr Blood Cancer. 2018 Jul;65(7):e27050
pubmed: 29630782
J Clin Oncol. 2001 Aug 1;19(15):3470-6
pubmed: 11481352
Pediatr Blood Cancer. 2013 Sep;60(9):1431-6
pubmed: 23610011
Neuro Oncol. 2016 Nov;18(11):1548-1558
pubmed: 27540084
J Clin Oncol. 2021 Mar 1;39(7):822-835
pubmed: 33405951
Acta Oncol. 2014 Apr;53(4):471-80
pubmed: 24564687
J Clin Oncol. 1995 Jun;13(6):1478-85
pubmed: 7751895
J Neurosurg Pediatr. 2016 Jul;18(1):29-40
pubmed: 27015518
J Clin Oncol. 2004 Feb 15;22(4):706-13
pubmed: 14966095
J Clin Oncol. 2020 Feb 10;38(5):454-461
pubmed: 31774710
Ital J Pediatr. 2014 Sep 26;40:74
pubmed: 25260976
Phys Med Biol. 2013 May 21;58(10):3107-23
pubmed: 23603657
Clin Endocrinol (Oxf). 2010 Nov;73(5):555-60
pubmed: 20039886
Int J Radiat Oncol Biol Phys. 2019 May 1;104(1):149-156
pubmed: 30684665
Radiother Oncol. 2018 Aug;128(2):192-197
pubmed: 29729847
Int J Radiat Oncol Biol Phys. 2013 Oct 1;87(2):228-30
pubmed: 23958143
Neurosurg Rev. 2022 Feb;45(1):243-251
pubmed: 34218360
Pediatr Hematol Oncol. 2015 Feb;32(1):78-83
pubmed: 23647507
Radiother Oncol. 2019 Jul;136:50-55
pubmed: 31015129
Radiother Oncol. 2018 May;127(2):280-286
pubmed: 29605477
Radiother Oncol. 2017 Apr;123(1):112-118
pubmed: 28283192
Radiother Oncol. 1998 Jul;48(1):23-7
pubmed: 9756168
Int J Radiat Oncol Biol Phys. 2010 Dec 1;78(5):1445-50
pubmed: 20231075
Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):892-9
pubmed: 18395355
Neuro Oncol. 2013 Jan;15(1):97-103
pubmed: 23099653
J Korean Med Sci. 2016 Nov;31(11):1726-1734
pubmed: 27709849
Neurology. 2017 Feb 21;88(8):789-796
pubmed: 28122904
Pediatr Blood Cancer. 2014 Feb;61(2):319-25
pubmed: 24127436
Technol Cancer Res Treat. 2016 Jun;15(3):472-9
pubmed: 25948323
Int J Radiat Oncol Biol Phys. 2012 Aug 1;83(5):e655-60
pubmed: 22768993
J Clin Virol. 2018 Jan;98:18-27
pubmed: 29197712
J Clin Oncol. 2016 Apr 1;34(10):1043-9
pubmed: 26811522
Neuro Oncol. 2016 Jun;18(6):881-7
pubmed: 26688075
J Clin Oncol. 2006 Sep 1;24(25):4202-8
pubmed: 16943538
Childs Nerv Syst. 2017 Nov;33(11):1969-1976
pubmed: 28770391
Med Pediatr Oncol. 1995 Feb;24(2):104-8
pubmed: 7990757