The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders.
central nervous system functions
m6A-modifying enzymes
n6-methyladenosine
neuropsychiatric disorders
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 May 2022
25 May 2022
Historique:
received:
14
04
2022
revised:
19
05
2022
accepted:
23
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
Epitranscriptomic modifications can affect every aspect of RNA biology, including stability, transport, splicing, and translation, participate in global intracellular mRNA metabolism, and regulate gene expression and a variety of biological processes. N6-methyladenosine (m6A) as the most prevalent modification contributes to normal embryonic brain development and memory formation. However, changes in the level of m6A modification and the expression of its related proteins cause abnormal nervous system functions, including brain tissue development retardation, axon regeneration disorders, memory changes, and neural stem cell renewal and differentiation disorders. Recent studies have revealed that m6A modification and its related proteins play key roles in the development of various neuropsychiatric disorders, such as depression, Alzheimer's disease, and Parkinson's disease. In this review, we summarize the research progresses of the m6A modification regulation mechanism in the central nervous system and discuss the effects of gene expression regulation mediated by m6A modification on the biological functions of the neuropsychiatric disorders, thereby providing some insight into new research targets and treatment directions for human diseases.
Identifiants
pubmed: 35682599
pii: ijms23115922
doi: 10.3390/ijms23115922
pmc: PMC9180340
pii:
doi:
Substances chimiques
RNA
63231-63-0
N-methyladenosine
CLE6G00625
Adenosine
K72T3FS567
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : (31871281)
Organisme : Scientific Research Foundation for Advanced Talents of Shanghai University of Traditional Chinese Medicine, the Shanghai Municipal Health Commission
ID : (2020XGKY12)
Organisme : Scientific Research Foundation of Shanghai Municipal Commission of Health and Family Planning
ID : (201840336)
Organisme : Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
ID : (JYJC201901)
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