Inhibitors of Mitochondrial Human Carbonic Anhydrases VA and VB as a Therapeutic Strategy against Paclitaxel-Induced Neuropathic Pain in Mice.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
02 Jun 2022
Historique:
received: 21 04 2022
revised: 26 05 2022
accepted: 30 05 2022
entrez: 10 6 2022
pubmed: 11 6 2022
medline: 14 6 2022
Statut: epublish

Résumé

Neuropathy development is a major dose-limiting side effect of anticancer treatments that significantly reduces patient's quality of life. The inadequate pharmacological approaches for neuropathic pain management warrant the identification of novel therapeutic targets. Mitochondrial dysfunctions that lead to reactive oxygen species (ROS) increase, cytosolic Ca

Identifiants

pubmed: 35682907
pii: ijms23116229
doi: 10.3390/ijms23116229
pmc: PMC9181376
pii:
doi:

Substances chimiques

Carbonic Anhydrase Inhibitors 0
Carbonic Anhydrases EC 4.2.1.1
Paclitaxel P88XT4IS4D

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Italian Ministry of University and Research
ID : not available
Organisme : University of Florence
ID : not available
Organisme : NeuroDeRisk
ID : 821528

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Auteurs

Laura Micheli (L)

Department of Neuroscience, Psychology, Drug Research and Child Health, NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.

Lara Testai (L)

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Andrea Angeli (A)

Department of Neuroscience, Psychology, Drug Research and Child Health, Pharmaceutical and Nutraceutical Sciences Section, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.

Donatello Carrino (D)

Department of Experimental and Clinical Medicine, Anatomy and Histology Section, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.

Alessandra Pacini (A)

Department of Experimental and Clinical Medicine, Anatomy and Histology Section, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.

Francesco Margiotta (F)

Department of Neuroscience, Psychology, Drug Research and Child Health, NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.

Lorenzo Flori (L)

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Claudiu T Supuran (CT)

Department of Neuroscience, Psychology, Drug Research and Child Health, Pharmaceutical and Nutraceutical Sciences Section, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.

Vincenzo Calderone (V)

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Carla Ghelardini (C)

Department of Neuroscience, Psychology, Drug Research and Child Health, NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.

Lorenzo Di Cesare Mannelli (L)

Department of Neuroscience, Psychology, Drug Research and Child Health, NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.

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Classifications MeSH