Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1.

Animals Cells, Cultured Conjunctiva / metabolism Docosahexaenoic Acids Goblet Cells / metabolism Mucins / metabolism Rats Rats, Sprague-Dawley Signal Transduction / physiology
epithelial cell eye inflammation intracellular Ca2+ mucin secretion tear film

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
02 Jun 2022
Historique:
received: 29 04 2022
revised: 24 05 2022
accepted: 25 05 2022
entrez: 10 6 2022
pubmed: 11 6 2022
medline: 14 6 2022
Statut: epublish

Résumé

Specialized pro-resolving mediators (SPMs), including Maresins (MaR)-1 and 2, contribute to tear film homeostasis and resolve conjunctival inflammation. We investigated MaR2's signaling pathways in goblet cells (GC) from rat conjunctiva. Agonist-induced [Ca

Identifiants

DOI: 10.3390/ijms23116233 PMID: 35682912 PMC: PMC9181304
pubmed: 35682912
pii: ijms23116233
doi: 10.3390/ijms23116233
pmc: PMC9181304
pii:
doi:

Substances chimiques

13,14-dihydroxydocosahexaenoic acid 0
7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid 0
Mucins 0
Docosahexaenoic Acids 25167-62-8

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Faculty of Medicine, University of Oslo
ID : N/A
Organisme : NIGMS NIH HHS
ID : R01 GM038765
Pays : United States
Organisme : Norwegian Research Council, Oslo, Norway
ID : N/A
Organisme : NEI NIH HHS
ID : R01EY019470
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01GM038765
Pays : United States
Organisme : Department of Medical Biochemistry, Oslo University Hospital
ID : N/A

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Auteurs

Markus V Olsen (MV)

Schepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway.
Department of Medical Biochemistry, Oslo University Hospital, 0424 Oslo, Norway.

Anne V Lyngstadaas (AV)

Schepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway.
Department of Medical Biochemistry, Oslo University Hospital, 0424 Oslo, Norway.

Jeffrey A Bair (JA)

Schepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.

Robin R Hodges (RR)

Schepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.

Tor P Utheim (TP)

Schepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Department of Plastic and Reconstructive Surgery, Oslo University Hospital, 0424 Oslo, Norway.

Charles N Serhan (CN)

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0003-4627-8545

Darlene A Dartt (DA)

Schepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Department of Oral Biology, Faculty of Dentistry, University of Oslo, 0316 Oslo, Norway.

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Classifications MeSH

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