The Sedentary Lifestyle and Masticatory Dysfunction: Time to Review the Contribution to Age-Associated Cognitive Decline and Astrocyte Morphotypes in the Dentate Gyrus.
aging
astrocyte morphometry
cognitive decline
dentate gyrus
environment
mastication
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Jun 2022
06 Jun 2022
Historique:
received:
29
04
2022
revised:
15
05
2022
accepted:
16
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
As aging and cognitive decline progresses, the impact of a sedentary lifestyle on the appearance of environment-dependent cellular morphologies in the brain becomes more apparent. Sedentary living is also associated with poor oral health, which is known to correlate with the rate of cognitive decline. Here, we will review the evidence for the interplay between mastication and environmental enrichment and assess the impact of each on the structure of the brain. In previous studies, we explored the relationship between behavior and the morphological features of dentate gyrus glial fibrillary acidic protein (GFAP)-positive astrocytes during aging in contrasting environments and in the context of induced masticatory dysfunction. Hierarchical cluster and discriminant analysis of GFAP-positive astrocytes from the dentate gyrus molecular layer revealed that the proportion of AST1 (astrocyte arbors with greater complexity phenotype) and AST2 (lower complexity) are differentially affected by environment, aging and masticatory dysfunction, but the relationship is not straightforward. Here we re-evaluated our previous reconstructions by comparing dorsal and ventral astrocyte morphologies in the dentate gyrus, and we found that morphological complexity was the variable that contributed most to cluster formation across the experimental groups. In general, reducing masticatory activity increases astrocyte morphological complexity, and the effect is most marked in the ventral dentate gyrus, whereas the effect of environment was more marked in the dorsal dentate gyrus. All morphotypes retained their basic structural organization in intact tissue, suggesting that they are subtypes with a non-proliferative astrocyte profile. In summary, the increased complexity of astrocytes in situations where neuronal loss and behavioral deficits are present is counterintuitive, but highlights the need to better understand the role of the astrocyte in these conditions.
Identifiants
pubmed: 35683023
pii: ijms23116342
doi: 10.3390/ijms23116342
pmc: PMC9180988
pii:
doi:
Substances chimiques
Glial Fibrillary Acidic Protein
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Council for Scientific and Technological Development
ID : 47677/2008-0
Organisme : Fundação Amazônia Paraense de Amparo à Pesquisa FAPESPA
ID : 136/08
Organisme : Pró-Reitoria de Pesquisa e Pós-Graduação PROPESP/UFPA
ID : Editing and Publication fees
Organisme : Coordenação de Aperfeicoamento de Pessoal de Nível Superior
ID : Bolsa Pós-Graduando
Organisme : Fundação de Amparo e Desenvolvimento da Pesquisa FADESP/UFPA
ID : Editing and Publication Fees
Organisme : Fundação para a Ciência e a Tecnologia
ID : Projects PTDC/MED-NEU/31395/2017, LISBOA-01-0145-FEDER-031395 and PTDC/MED-NEU/2382/2021
Organisme : iMed.ULisboa
ID : part UID/DTP/04138/2019-2021
Organisme : "la Caixa" Foundation
ID : HR21-00931
Références
Front Neural Circuits. 2021 Mar 22;15:658343
pubmed: 33828463
Alzheimers Res Ther. 2019 Jul 27;11(1):64
pubmed: 31351489
Science. 2021 Nov 26;374(6571):1106-1113
pubmed: 34672693
Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13602-13610
pubmed: 31152131
Neurosci Res. 2009 Aug;64(4):385-90
pubmed: 19393269
Exp Gerontol. 2001 Feb;36(2):283-95
pubmed: 11226743
Neurosci Lett. 2013 Feb 8;534:228-32
pubmed: 23262093
BMC Neurosci. 2016 Dec 5;17(1):81
pubmed: 27919226
Neurosci Lett. 2007 Mar 6;414(2):188-91
pubmed: 17207572
J Neurosci. 2018 Mar 14;38(11):2698-2712
pubmed: 29431646
Neurobiol Aging. 2021 Jul;103:68-77
pubmed: 33845398
Front Aging Neurosci. 2021 Dec 01;13:766306
pubmed: 34924995
Gerodontology. 2019 Mar;36(1):2-7
pubmed: 30480331
Learn Mem. 2013 Oct 16;20(11):642-7
pubmed: 24131795
Biomed Res. 2007 Feb;28(1):1-7
pubmed: 17379951
Physiol Behav. 2015 Dec 1;152(Pt A):231-7
pubmed: 26454210
J Neurosci Res. 2021 Feb;99(2):518-528
pubmed: 33164225
Biochem Biophys Res Commun. 2018 Apr 6;498(3):621-626
pubmed: 29524403
Neurobiol Aging. 2014 Jan;35(1):15-23
pubmed: 23969179
PLoS One. 2012;7(6):e38971
pubmed: 22701737
Cell. 2018 Jun 28;174(1):12-13
pubmed: 29958102
Eur J Histochem. 2021 Jun 23;65(s1):
pubmed: 34346664
Health (London). 2021 Nov 2;:13634593211049891
pubmed: 34727785
Behav Brain Res. 2000 Mar;108(2):145-55
pubmed: 10701658
Neuron. 2010 Jan 14;65(1):7-19
pubmed: 20152109
Aging (Albany NY). 2021 Sep 7;13(17):21599-21609
pubmed: 34495870
Neuroscience. 2015 Aug 20;301:454-70
pubmed: 26116517
Biochim Biophys Acta Gene Regul Mech. 2020 Jun;1863(6):194491
pubmed: 32006715
Jpn Dent Sci Rev. 2018 Nov;54(4):169-173
pubmed: 30302135
BMC Biol. 2022 Jan 13;20(1):15
pubmed: 35022024
Nat Commun. 2019 Jul 4;10(1):2968
pubmed: 31273206
Nat Commun. 2020 Mar 5;11(1):1220
pubmed: 32139688
Technol Health Care. 2021;29(S1):125-131
pubmed: 33682752
Pflugers Arch. 2021 May;473(5):753-774
pubmed: 32979108
Neuropsychopharmacology. 2017 Jul;42(8):1715-1728
pubmed: 28294135
Biomed Res Int. 2015;2015:294068
pubmed: 26075223
Okajimas Folia Anat Jpn. 2007 Nov;84(3):115-9
pubmed: 18186225
J Comp Neurol. 2019 May 1;527(7):1179-1195
pubmed: 30578640
PLoS One. 2011;6(10):e26812
pubmed: 22046366
Int J Mol Sci. 2017 Aug 03;18(8):
pubmed: 28771175
Neuromolecular Med. 2008;10(2):128-40
pubmed: 18286389
Nat Neurosci. 2007 Mar;10(3):331-9
pubmed: 17310248
Cells. 2021 Jun 18;10(6):
pubmed: 34207393
Aging Dis. 2021 Oct 1;12(7):1644-1657
pubmed: 34631212
J Oral Rehabil. 2018 Dec;45(12):990-997
pubmed: 30126006
Front Aging Neurosci. 2020 Jun 09;12:148
pubmed: 32581763
Aging Cell. 2022 Jan;21(1):e13521
pubmed: 34894056
Front Neural Circuits. 2022 Jan 04;15:786293
pubmed: 35069124
Leg Med (Tokyo). 2006 May;8(3):161-5
pubmed: 16621651
Front Neurosci. 2019 Mar 14;13:107
pubmed: 30930726
Cold Spring Harb Perspect Med. 2018 Apr 2;8(4):
pubmed: 28495803
Glia. 2016 Dec;64(12):2263-2273
pubmed: 27658520
Front Aging Neurosci. 2019 Mar 19;11:59
pubmed: 30941031
Hippocampus. 2019 Dec;29(12):1238-1254
pubmed: 31408260
Bio Protoc. 2020 Jun 05;10(11):e3637
pubmed: 33659308
Physiol Behav. 2018 May 1;188:239-250
pubmed: 29452151
Clin Oral Investig. 2022 Apr;26(4):3493-3500
pubmed: 34881401
PLoS One. 2013 Sep 16;8(9):e74966
pubmed: 24066161
Arch Gerontol Geriatr. 2017 May - Jun;70:44-53
pubmed: 28042986
Neuron. 2017 Aug 2;95(3):531-549.e9
pubmed: 28712653
Brain Res. 2001 Jun 1;902(2):255-63
pubmed: 11384619
Physiol Int. 2019 Mar 1;106(1):21-28
pubmed: 30888219
Neurobiol Learn Mem. 2014 Oct;114:16-25
pubmed: 24727294
Aging Cell. 2019 Jun;18(3):e12937
pubmed: 30815970
BMC Neurosci. 2012 Feb 29;13:23
pubmed: 22376223
Behav Brain Funct. 2016 Oct 10;12(1):28
pubmed: 27719674
BMC Oral Health. 2021 Dec 27;21(1):665
pubmed: 34961506
J Cereb Blood Flow Metab. 2021 Oct;41(10):2607-2616
pubmed: 33866848
Neuroscience. 2011 Apr 28;180:41-52
pubmed: 21320577
Learn Mem. 2011 Aug 30;18(9):605-9
pubmed: 21878528
Neuroscience. 2016 May 26;323:170-82
pubmed: 25595973
Sports Med. 2020 Feb;50(2):403-413
pubmed: 31529300
Trends Ecol Evol. 2012 Aug;27(8):452-61
pubmed: 22727728
Curr Biol. 2022 Feb 28;32(4):834-841.e5
pubmed: 35016008
PLoS One. 2020 Aug 20;15(8):e0237872
pubmed: 32817680
Neuron. 2021 Feb 17;109(4):576-596
pubmed: 33385325
Jpn Dent Sci Rev. 2018 Aug;54(3):118-126
pubmed: 30128059
Neuron. 2016 Feb 17;89(4):857-66
pubmed: 26853301
Biomed Res Int. 2015;2015:876409
pubmed: 26090453
Hippocampus. 2020 Sep;30(9):938-957
pubmed: 32285544
Nat Rev Neurosci. 2019 Apr;20(4):235-245
pubmed: 30723309
J Neurosci. 2022 Mar 16;42(11):2356-2370
pubmed: 35105676
BMC Oral Health. 2018 Aug 20;18(1):142
pubmed: 30126407
Brain Struct Funct. 2014 Jan;219(1):293-302
pubmed: 23288255
Behav Brain Res. 2017 Jan 15;317:332-339
pubmed: 27702635
Oxid Med Cell Longev. 2017;2017:4504925
pubmed: 28243355
Gerodontology. 2021 Jun;38(2):126-135
pubmed: 33179281
Front Neurosci. 2022 Feb 10;16:811335
pubmed: 35221901
J Dent Res. 2017 Aug;96(9):1058-1066
pubmed: 28621563
Neurosci Biobehav Rev. 2015 Aug;55:268-79
pubmed: 25976634
J Pharm Bioallied Sci. 2021 Jun;13(Suppl 1):S788-S794
pubmed: 34447202
Adv Exp Med Biol. 2019;1175:149-179
pubmed: 31583588
J Dent Res. 2001 Dec;80(12):2089-92
pubmed: 11808768
Cell Rep. 2018 Jan 2;22(1):269-285
pubmed: 29298427
Neuroimage. 2019 May 1;191:568-586
pubmed: 30742981
BMC Neurosci. 2013 Jun 28;14:63
pubmed: 23805920
Trends Neurosci. 2014 Oct;37(10):604-14
pubmed: 25257207
Trends Immunol. 2020 Sep;41(9):758-770
pubmed: 32819810
Int J Mol Sci. 2020 Jan 28;21(3):
pubmed: 32012921
Arch Oral Biol. 2016 Jan;61:1-7
pubmed: 26476746
Neurobiol Aging. 2021 Apr;100:59-71
pubmed: 33493951
Neuroscience. 2018 Feb 1;370:14-26
pubmed: 28571720
Neuroscientist. 2018 Oct;24(5):516-525
pubmed: 29877135
J Neurosci Res. 2019 Sep;97(9):1081-1094
pubmed: 31175682
J Neurosci. 2017 May 10;37(19):4868-4882
pubmed: 28385873
J Oral Rehabil. 2010 Aug;37(8):624-40
pubmed: 20236235
J Clin Invest. 2015 Apr;125(4):1497-508
pubmed: 25751059
Eur J Neurosci. 2010 Aug;32(3):509-19
pubmed: 20704596
Front Synaptic Neurosci. 2020 Mar 17;12:10
pubmed: 32256333
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1896-E1905
pubmed: 29437957
Nat Neurosci. 2021 Mar;24(3):312-325
pubmed: 33589835
Glia. 2022 Aug;70(8):1484-1505
pubmed: 34582594
Hippocampus. 2013 Jun;23(6):437-50
pubmed: 23460346
Front Physiol. 2019 Jul 03;10:832
pubmed: 31333490
Neuroscience. 2012 May 3;209:74-83
pubmed: 22285310
Proteomics. 2003 Aug;3(8):1476-85
pubmed: 12923773
Neurotherapeutics. 2019 Jul;16(3):543-553
pubmed: 31161490
PLoS One. 2014 Jan 23;9(1):e86237
pubmed: 24465980
Hippocampus. 2003;13(1):133-49
pubmed: 12625464
Elife. 2020 Sep 01;9:
pubmed: 32869747
Okajimas Folia Anat Jpn. 2010 Nov;87(3):135-40
pubmed: 21174943
Physiol Behav. 2014 Aug;135:55-71
pubmed: 24910138
Front Synaptic Neurosci. 2019 Oct 15;11:28
pubmed: 31680927
Glia. 2022 Aug;70(8):1536-1553
pubmed: 34904753
Front Cell Neurosci. 2021 Jul 26;15:703810
pubmed: 34381334
Int Dent J. 2019 Oct;69(5):334-340
pubmed: 31140598
Neuroscience. 2014 Feb 28;260:158-70
pubmed: 24361917
Neuroscience. 2021 Feb 21;456:71-84
pubmed: 32224231
Aging (Albany NY). 2021 Mar 19;13(6):7943-7952
pubmed: 33739304
Neuroscience. 2008 Jul 17;154(4):1352-9
pubmed: 18534765
Neurochem Int. 2019 Mar;124:1-9
pubmed: 30529642
Behav Brain Res. 2013 Sep 15;253:178-90
pubmed: 23860119
Front Neurosci. 2021 Apr 15;15:632216
pubmed: 33935629
Neurobiol Learn Mem. 2020 Dec;176:107323
pubmed: 33053429
Brain Pathol. 2017 Sep;27(5):645-674
pubmed: 28804999
Front Neurosci. 2021 Jun 16;15:594448
pubmed: 34220412
BMC Geriatr. 2018 Jan 5;18(1):5
pubmed: 29304748
Brain Res. 2005 Sep 28;1057(1-2):191-5
pubmed: 16112090
eNeuro. 2021 Mar 12;8(2):
pubmed: 33622702
Brain Imaging Behav. 2020 Feb;14(1):175-185
pubmed: 30382528
Nat Commun. 2018 Jan 19;9(1):298
pubmed: 29352183
Okajimas Folia Anat Jpn. 2008 May;85(1):35-42
pubmed: 18833910
Biochem Biophys Res Commun. 2022 Feb 26;594:74-80
pubmed: 35078110
J Clin Med. 2021 Aug 24;10(17):
pubmed: 34501210
Curr Opin Neurobiol. 2020 Aug;63:189-197
pubmed: 32659458
Neuropharmacology. 2019 Feb;145(Pt A):59-74
pubmed: 29630903
Science. 2021 Nov 26;374(6571):1049-1050
pubmed: 34822282
Front Behav Neurosci. 2021 Mar 09;15:595049
pubmed: 33767614
Neuromolecular Med. 2011 Sep;13(3):197-203
pubmed: 21751079
Brain Res. 2009 Jun 5;1274:47-54
pubmed: 19374889
Int J Mol Sci. 2020 May 15;21(10):
pubmed: 32429128
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:165-175
pubmed: 28185964
Cells. 2021 Mar 04;10(3):
pubmed: 33806259
Brain Struct Funct. 2014 Jul;219(4):1509-10
pubmed: 23644588
Int J Med Sci. 2015 Jun 09;12(6):502-9
pubmed: 26078711
Hippocampus. 2018 Feb;28(2):178-185
pubmed: 29232477
Behav Brain Res. 2013 May 15;245:34-41
pubmed: 23428744
Br Dent J. 2018 Jan;223(11):846-853
pubmed: 29192686
Front Cell Neurosci. 2018 Jun 26;12:177
pubmed: 29997480
Front Synaptic Neurosci. 2020 Jun 18;12:24
pubmed: 32625076
Physiology (Bethesda). 2017 Nov;32(6):410-424
pubmed: 29021361
Spec Care Dentist. 2019 May;39(3):262-273
pubmed: 30964560
Nat Commun. 2020 Jul 23;11(1):3689
pubmed: 32704144
Nat Commun. 2020 Mar 13;11(1):1382
pubmed: 32170133
Annu Rev Neurosci. 2007;30:123-52
pubmed: 17417939
J Vis Exp. 2008 Dec 22;(22):
pubmed: 19229173
Mol Brain. 2021 Sep 20;14(1):144
pubmed: 34544455
Neuron. 2020 Mar 18;105(6):1036-1047.e5
pubmed: 31954621
Int J Environ Res Public Health. 2019 Nov 18;16(22):
pubmed: 31752149
Int J Mol Sci. 2019 Feb 21;20(4):
pubmed: 30795555
Neurochem Res. 2020 Oct;45(10):2417-2432
pubmed: 32748366
Cell. 2018 Jun 28;174(1):59-71.e14
pubmed: 29804835
Nat Commun. 2016 Jun 16;7:11937
pubmed: 27306314
Elife. 2021 Mar 17;10:
pubmed: 33729913
Cereb Cortex. 2020 May 18;30(6):3744-3758
pubmed: 31989153