Polymeric Micelles Enhance Mucosal Contact Time and Deposition of Fluocinolone Acetonide.
drug–mucin contact time
focal plane array (FPA)-based Fourier transform infrared (FTIR) imaging
hydrophobic drug
mouth rinse
polymeric micelles
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
31 May 2022
31 May 2022
Historique:
received:
17
05
2022
revised:
28
05
2022
accepted:
29
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
11
6
2022
Statut:
epublish
Résumé
This study used polymeric micelles to improve quality by increasing drug solubility, extending mucosal drug retention time, enhancing mucoadhesiveness, and promoting drug permeation and deposition. Fluocinolone acetonide (FA) was loaded into polymeric micelles (FPM), which were composed of poloxamer 407 (P407), sodium polyacrylate (SPA), and polyethylene glycol 400, and their physicochemical properties were examined. Small-angle X-ray scattering (SAXS) revealed a hexagonal micellar structure at all temperatures, and the concentrations of P407 and SPA were shown to significantly affect the solubility, mucoadhesion, release, and permeation of FPMs. The proportion of P407 to PEG at a ratio of 7.5:15 with or without 0.1%
Identifiants
pubmed: 35683926
pii: polym14112247
doi: 10.3390/polym14112247
pmc: PMC9182893
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Research Institute of Rangsit University, Thailand
ID : Grant no. 59/2563
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