Therapeutic Potential of Natural Products in the Treatment of Renal Cell Carcinoma: A Review.
anti-cancer
natural products
renal cell carcinoma
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
28 May 2022
28 May 2022
Historique:
received:
05
05
2022
revised:
25
05
2022
accepted:
26
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
Renal cell carcinoma (RCC) is a common cancer of the urinary system. The potential therapeutic effects of certain natural products against renal cell carcinoma have been reported both in vivo and in vitro, but no reviews have been published classifying and summarizing the mechanisms of action of various natural products. In this study, we used PubMed and Google Scholar to collect and screen the recent literature on natural products with anti-renal-cancer effects. The main mechanisms of action of these products include the induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis and reduction of drug resistance. In total, we examined more than 30 natural products, which include kahweol acetate, honokiol, englerin A and epigallocatechin-3-gallate, among others, have demonstrated a variety of anti-renal-cancer effects. In conclusion, natural products may have a wider application in kidney cancer than previously believed and are potential candidates for treatment in RCC.
Identifiants
pubmed: 35684073
pii: nu14112274
doi: 10.3390/nu14112274
pmc: PMC9182762
pii:
doi:
Substances chimiques
Biological Products
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Beijing Advanced Innovation Center for Food Nutrition and Human Health of Beijing Technology and Business University
ID : 20181031
Organisme : National Natural Science Foundation of China
ID : 81874123
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