Oleuropein Counteracts Both the Proliferation and Migration of Intra- and Extragonadal Seminoma Cells.
BAX
NF-κB pathway
apoptosis
oleuropein
seminoma
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
31 May 2022
31 May 2022
Historique:
received:
21
04
2022
revised:
21
05
2022
accepted:
28
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
Recent and growing literature has reported that oleuropein (OLE), the main polyphenol in olive leaf extract, inhibits tumor cell proliferation and reduces the invasiveness properties of cancer cells; therefore, OLE may play a significant role in the development of new drugs for cancer treatment. These antineoplastic properties have been reported in many experimental cancer models, but the effect of OLE on seminoma cells is yet to be evaluated. In the present study, we demonstrate, for the first time, that OLE reduces cell viability in both intra- and extragonadal TCAM-2 and SEM-1 seminoma cells, respectively, in a dose-dependent manner. As shown by Western-blot analysis, OLE exposure reduced cyclin-D1 expression and upregulated p21
Identifiants
pubmed: 35684123
pii: nu14112323
doi: 10.3390/nu14112323
pmc: PMC9182631
pii:
doi:
Substances chimiques
Iridoid Glucosides
0
Iridoids
0
NF-kappa B
0
Plant Extracts
0
oleuropein
2O4553545L
olive leaf extract
MJ95C3OH47
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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