Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway.
Nobiletin
P53 signaling pathway
RUPP
hypoxia
placenta
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
01 Jun 2022
01 Jun 2022
Historique:
received:
28
03
2022
revised:
24
05
2022
accepted:
30
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
In this study, we aimed to evaluate the effect of Nobiletin (NOB) on the placenta of Sprague-Dawley (SD) rats that had undergone reduced uterine perfusion pressure (RUPP) surgery and to evaluate the safety of NOB intervention during pregnancy. The results showed that NOB alleviated placental hypoxia, attenuated placental cell apoptosis, and inhibited placental damage in RUPP rats. No side effect of NOB intervention during pregnancy was observed. BeWo cell lines with P53 knockdown were then constructed using lentiviral transfection, and the P53 signaling pathway was found to be essential for NOB to reduce hypoxia-induced apoptosis of the BeWo cell lines. In summary, NOB attenuated hypoxia-induced placental damage by regulating the P53 signaling pathway, and those findings may contribute some insights into the role of NOB in placental development and the prevention of placental-related diseases.
Identifiants
pubmed: 35684132
pii: nu14112332
doi: 10.3390/nu14112332
pmc: PMC9183106
pii:
doi:
Substances chimiques
Flavones
0
Tumor Suppressor Protein p53
0
nobiletin
D65ILJ7WLY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Key Research and Development Program of China
ID : No. 2017YFD0400701-1
Organisme : National Natural Science Foundation of China
ID : No. 82073553
Références
BMJ. 2021 Sep 22;374:n2103
pubmed: 34551918
Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188556
pubmed: 33932560
PPAR Res. 2021 Aug 06;2021:9947656
pubmed: 34422028
Trends Cell Biol. 2021 Apr;31(4):298-310
pubmed: 33518400
Mol Cancer. 2019 Nov 11;18(1):157
pubmed: 31711497
Redox Biol. 2021 Jan;38:101814
pubmed: 33321463
J Agric Food Chem. 2020 Jul 8;68(27):7112-7120
pubmed: 32538091
Am J Transl Res. 2019 Sep 15;11(9):5967-5977
pubmed: 31632564
Cell Death Dis. 2019 Feb 21;10(3):177
pubmed: 30792387
Hypertension. 2018 May;71(5):886-893
pubmed: 29555668
Hypertension. 2020 Feb;75(2):561-568
pubmed: 31865793
Int J Mol Sci. 2020 Jul 27;21(15):
pubmed: 32727154
Clin Sci (Lond). 2020 Mar 27;134(6):571-592
pubmed: 32129440
Molecules. 2020 Feb 20;25(4):
pubmed: 32093273
Sci Rep. 2022 Jan 21;12(1):1111
pubmed: 35064159
Biochim Biophys Acta Mol Basis Dis. 2020 Feb 1;1866(2):165373
pubmed: 30684642
Ultrasound Obstet Gynecol. 2021 Oct;58(4):546-552
pubmed: 33998099
Hum Reprod Update. 2021 Apr 21;27(3):531-569
pubmed: 33377492
Nat Commun. 2021 Feb 12;12(1):986
pubmed: 33579943
Am J Physiol Heart Circ Physiol. 2012 Jul;303(1):H1-8
pubmed: 22523250
Int J Mol Sci. 2019 Dec 31;21(1):
pubmed: 31906255
J Am Coll Cardiol. 2020 Oct 6;76(14):1690-1702
pubmed: 33004135
Sci Rep. 2018 Nov 21;8(1):17162
pubmed: 30464252
J Agric Food Chem. 2020 Feb 5;68(5):1326-1336
pubmed: 31955565
Nutrients. 2019 Feb 12;11(2):
pubmed: 30759768
Physiol Rev. 2021 Jul 1;101(3):739-795
pubmed: 33270534
Food Nutr Res. 2021 Sep 24;65:
pubmed: 34650395
Life Sci. 2019 Dec 15;239:117038
pubmed: 31730868
Int J Mol Sci. 2019 Jul 02;20(13):
pubmed: 31269775
Cell Mol Life Sci. 2019 Sep;76(18):3479-3496
pubmed: 31049600
Biochem Biophys Res Commun. 2020 Jan 15;521(3):769-774
pubmed: 31703840
Nat Rev Endocrinol. 2020 Sep;16(9):479-494
pubmed: 32601352
Antioxidants (Basel). 2020 May 12;9(5):
pubmed: 32408702
Acta Obstet Gynecol Scand. 2020 Feb;99(2):167-174
pubmed: 31519033