Dietary and Nutrient Patterns and Brain MRI Biomarkers in Dementia-Free Adults.


Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
03 Jun 2022
Historique:
received: 08 04 2022
revised: 28 05 2022
accepted: 31 05 2022
entrez: 10 6 2022
pubmed: 11 6 2022
medline: 14 6 2022
Statut: epublish

Résumé

Cognitive impairment is a rapidly growing public health problem. As there is no curative treatment for dementia, the proactive management of modifiable risk factors and the identification of early biomarkers indicative of the cognitive decline are of great importance. Although nutrition is one of the most extensively studied lifestyle factor in relation to cognitive health, its association with brain magnetic resonance imaging (MRI) biomarkers is not well established. In the present work, we review available studies relating dietary or nutrient patterns with brain MRI biomarkers in dementia-free adults. Greater adherence to the Mediterranean diet has been associated with the preservation of structural connectivity and less brain atrophy in adults without dementia. In addition, specific nutrient patterns, characterized by a high intake of antioxidant vitamins, polyphenols and unsaturated fatty acids, have been related to larger brain volume. Although the results are encouraging regarding the role of dietary and nutrient patterns on imaging biomarkers, more well-designed observational longitudinal studies and clinical trials are needed in order to confirm potentially causal relationships and better understand underlying mechanisms.

Identifiants

pubmed: 35684145
pii: nu14112345
doi: 10.3390/nu14112345
pmc: PMC9183163
pii:
doi:

Substances chimiques

Biomarkers 0
Vitamins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Archontoula Drouka (A)

Department of Nutrition and Dietetics, Harokopio University, 176 71 Athens, Greece.

Eirini Mamalaki (E)

Department of Nutrition and Dietetics, Harokopio University, 176 71 Athens, Greece.

Efstratios Karavasilis (E)

School of Medicine, Democritus University of Thrace, 68100 Alexandroupoli, Greece.

Nikolaos Scarmeas (N)

1st Department of Neurology, Medical School, National and Kapodistrian University of Athens, Aeginition University Hospital, 115 28 Athens, Greece.
The Gertrude H. Sergievsky Center, Department of Neurology, Taub Institute for Research in Alzheimer's, Disease and the Aging Brain, Columbia University, New York, NY 10027, USA.

Mary Yannakoulia (M)

Department of Nutrition and Dietetics, Harokopio University, 176 71 Athens, Greece.

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Classifications MeSH