1-Mesityl-3-(3-Sulfonatopropyl) Imidazolium Protects Against Oxidative Stress and Delays Proteotoxicity in
Caenorhabditis elegans
imidazolium salts
neurodegenerative disease
oxidative stress
proteotoxicity
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
30
03
2022
accepted:
28
04
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
11
6
2022
Statut:
epublish
Résumé
Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases (NDs) have become more prevalent. Conventional treatments comprise drugs that only attenuate some of the symptoms, but fail to arrest or delay neuronal proteotoxicity that characterizes these diseases. Due to their diverse biological activities, imidazole rings are intensively explored as powerful scaffolds for the development of new bioactive molecules. By using
Identifiants
pubmed: 35685626
doi: 10.3389/fphar.2022.908696
pii: 908696
pmc: PMC9171001
doi:
Types de publication
Journal Article
Langues
eng
Pagination
908696Informations de copyright
Copyright © 2022 Andersen, Veuthey, Blanco, Silbestri, Rayes and De Rosa.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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