Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life.
early life
extensively hydrolyzed infant formula
intestinal permeability
lipidome
lipidomics
metabolomics
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
01
2022
accepted:
11
04
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
11
6
2022
Statut:
epublish
Résumé
Current evidence suggests that the composition of infant formula (IF) affects the gut microbiome, intestinal function, and immune responses during infancy. However, the impact of IF on circulating lipid profiles in infants is still poorly understood. The objectives of this study were to (1) investigate how extensively hydrolyzed IF impacts serum lipidome compared to conventional formula and (2) to associate changes in circulatory lipids with gastrointestinal biomarkers including intestinal permeability. In a randomized, double-blind controlled nutritional intervention study ( Concentrations of sphingomyelins were higher in the HF group as compared to the RF group. Triacylglycerols (TGs) containing saturated and monounsaturated fatty acyl chains were found in higher levels in the HF group at 3 months, but downregulated at 9 and 12 months of age. LM ratio was lower in the HF group at 9 months of age. In the RF group, the LM ratio was positively associated with ether-linked lipids. Such an association was, however, not observed in the HF group. Our study suggests that HF intervention changes the circulating lipidome, including those lipids previously found to be associated with progression to islet autoimmunity or overt T1D. [Clinicaltrials.gov], identifier [NCT01735123].
Sections du résumé
Background
UNASSIGNED
Current evidence suggests that the composition of infant formula (IF) affects the gut microbiome, intestinal function, and immune responses during infancy. However, the impact of IF on circulating lipid profiles in infants is still poorly understood. The objectives of this study were to (1) investigate how extensively hydrolyzed IF impacts serum lipidome compared to conventional formula and (2) to associate changes in circulatory lipids with gastrointestinal biomarkers including intestinal permeability.
Methods
UNASSIGNED
In a randomized, double-blind controlled nutritional intervention study (
Results
UNASSIGNED
Concentrations of sphingomyelins were higher in the HF group as compared to the RF group. Triacylglycerols (TGs) containing saturated and monounsaturated fatty acyl chains were found in higher levels in the HF group at 3 months, but downregulated at 9 and 12 months of age. LM ratio was lower in the HF group at 9 months of age. In the RF group, the LM ratio was positively associated with ether-linked lipids. Such an association was, however, not observed in the HF group.
Conclusion
UNASSIGNED
Our study suggests that HF intervention changes the circulating lipidome, including those lipids previously found to be associated with progression to islet autoimmunity or overt T1D.
Clinical Trial Registration
UNASSIGNED
[Clinicaltrials.gov], identifier [NCT01735123].
Identifiants
pubmed: 35685890
doi: 10.3389/fnut.2022.859627
pmc: PMC9171511
doi:
Banques de données
ClinicalTrials.gov
['NCT01735123']
Types de publication
Journal Article
Langues
eng
Pagination
859627Informations de copyright
Copyright © 2022 Lamichhane, Siljander, Salonen, Ruohtula, Virtanen, Ilonen, Hyötyläinen, Knip and Orešič.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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