Clinical Discordance in Monozygotic Twins With Autism Spectrum Disorder.
attention-deficit/ hyperactivity disorder
autism spectrum disorder (asd)
identical twins
monozygotic twins
unexplained syncope
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
accepted:
07
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
11
6
2022
Statut:
epublish
Résumé
There is a significant concordance of autism spectrum disorder in monozygotic (MZ) twins, where behavioral manifestations are heavily influenced by genetic factors. We describe a case of male monozygotic twins with autism spectrum disorder (ASD), raised in the same household, that present with different clinical manifestations. One of the twins presents with intermittent frank syncopal episodes, sinus bradycardia, and elevated alkaline phosphatase (ALP), while the other has symptoms of attention-deficit/hyperactivity disorder (ADHD), normal cardiological findings, and normal ALP level. The clinical discordance in this pair of monozygotic twins may be due to any of the following: 1) neuroanatomic cerebellar differences, 2) variable expression of genotype, and 3) inconsistent neurotransmitter regulation.
Identifiants
pubmed: 35686266
doi: 10.7759/cureus.24813
pmc: PMC9170280
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e24813Informations de copyright
Copyright © 2022, Ho et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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