Transcriptional Analysis for Tuberculosis in Pregnant Women From the PRegnancy Associated Changes In Tuberculosis Immunology (PRACHITi) Study.

A new tuberculosis (TB) diagnostic cartridge assay, which detects a 3-gene TB signature in whole blood, was not diagnostic in women with maternal TB disease in India (area under the curve [AUC] = 0.72). In a cohort of pregnant women, we identified a novel gene set for TB diagnosis (AUC = 0.97) and one for TB progression (AUC = 0.96).

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

Déclaration de conflit d'intérêts

Potential conflicts of interest. A. G. receives support from the Gilead Foundation, the Makhija Foundation, and the Wyncote Foundation; reports grants or contracts unrelated to this work from NIH, Unitaid, and the Centers for Disease Control and Prevention; reports participation on a data and safety monitoring board or advisory board for the NIH/NIAID Advisory Council and Indo US Science Technology Governing Board; and reports a leadership or fiduciary role with the International Maternal Pediatric and Adolescent AIDS Clinical Trial Network TB Scientific Committee and World Health Organization Multidrug-Resistant Tuberculosis Guidelines Committee. J. S. M. reports grants or contracts unrelated to this work and support for attending meetings and/or travel from the NIH, paid to institution, and the Aurum Institute. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.