The Number of Lymph Nodes Examined is Associated with Survival Outcomes of Neuroendocrine Tumors of the Jejunum and Ileum (siNET): Development and Validation of a Prognostic Model Based on SEER Database.
Ileum
Jejunum
Lymph nodes examination
Neuroendocrine tumors
Nomogram
Journal
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
ISSN: 1873-4626
Titre abrégé: J Gastrointest Surg
Pays: United States
ID NLM: 9706084
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
24
03
2022
accepted:
15
05
2022
pubmed:
11
6
2022
medline:
24
9
2022
entrez:
10
6
2022
Statut:
ppublish
Résumé
The number of neuroendocrine tumors (NETs) is gradually increasing worldwide, and those located in the small intestine (siNETs) are the most common. As some biological and clinical characteristics of tumors of the jejunum and the ileum differ, there is a need to assess the prognosis of individuals with siNETs of the jejunum and ileum separately. We generated a predictive nomogram by assessing individuals with siNETs from the Surveillance, Epidemiology, and End Results (SEER) database. We used univariate Cox regression analysis to determine both the overall survival (OS) and the cancer-specific survival (CSS) of 2501 patients with a pathological confirmation of siNETs of the jejunum and ileum. To predict 3-, 5-, and 10-year OS of siNETs, a nomogram was generated based on a training cohort and validated with an external cohort. Accuracy and clinical practicability were evaluated separately by Harrell's C-indices, calibration plots, and decision curves. The correlation was examined between dissected lymph nodes and positive lymph nodes. Dissection of 7 or more lymph nodes significantly improved patient OS and was found to be a protective factor for patients with siNETs. In Cox regression analyses, age, primary site, tumor size, N stage, M stage, and regional lymph node examination were significant predictors in the nomogram. A significant positive correlation was found between dissected lymph nodes and positive lymph nodes. Patients with 7 or more dissected lymph nodes showed an accurate tumor stage and a better prognosis. Our nomogram accurately predicted the OS of patients with siNETs.
Identifiants
pubmed: 35689008
doi: 10.1007/s11605-022-05359-0
pii: 10.1007/s11605-022-05359-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1917-1929Informations de copyright
© 2022. The Society for Surgery of the Alimentary Tract.
Références
Yao J C, Hassan M, Phan A, et al. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States[J]. J Clin Oncol, 2008, 26(18): 3063-72.
pubmed: 18565894
Dasari B V M, Al-Shakhshir S, Pawlik T M, et al. Outcomes of surgical and endoscopic resection of duodenal neuroendocrine tumours (NETs): a systematic review of the literature[J]. J Gastrointest Surg, 2018, 22(9): 1652-1658.
pubmed: 29869091
Shroff S R, Kushnir V M, Wani S B, et al. Efficacy of endoscopic mucosal resection for management of small duodenal neuroendocrine tumors[J]. Surg Laparosc Endosc Percutan Tech, 2015, 25(5): e134-9.
pubmed: 26271024
Casali P G, Blay J Y, Abecassis N, et al. Gastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up[J]. Ann Oncol, 2022, 33(1): 20-33.
pubmed: 34560242
Motz B M, Lorimer P D, Boselli D, et al. Optimal lymphadenectomy in small bowel neuroendocrine tumors: analysis of the NCDB[J]. J Gastrointest Surg, 2018, 22(1): 117-123.
pubmed: 28819895
Zaidi M Y, Lopez-Aguiar A G, Dillhoff M, et al. Prognostic role of lymph node positivity and number of lymph nodes needed for accurately staging small-bowel neuroendocrine tumors[J]. JAMA Surg, 2019, 154(2): 134-140.
pubmed: 30383112
Lipiński M, Rydzewska G, Foltyn W, et al. Gastroduodenal neuroendocrine neoplasms, including gastrinoma - management guidelines (recommended by the Polish Network of Neuroendocrine Tumours)[J]. Endokrynol Pol, 2017, 68(2): 138-153.
pubmed: 28540972
Iasonos A, Schrag D, Raj G V, et al. How to build and interpret a nomogram for cancer prognosis[J]. J Clin Oncol, 2008, 26(8): 1364-70.
pubmed: 18323559
Callegaro D, Miceli R, Mariani L, et al. Soft tissue sarcoma nomograms and their incorporation into practice[J]. Cancer, 2017, 123(15): 2802-2820.
pubmed: 28493287
Caulfield S, Menezes G, Marignol L, et al. Nomograms are key decision-making tools in prostate cancer radiation therapy[J]. Urol Oncol, 2018, 36(6): 283-292.
pubmed: 29680180
Prentice R L, Kalbfleisch J D. Hazard rate models with covariates[J]. Biometrics, 1979, 35(1): 25-39.
pubmed: 497336
Schober P, Boer C, Schwarte L A. Correlation coefficients: appropriate use and interpretation[J]. Anesth Analg, 2018, 126(5): 1763-1768.
pubmed: 29481436
Vickers A J, Elkin E B. Decision curve analysis: a novel method for evaluating prediction models[J]. Med Decis Making, 2006, 26(6): 565-74.
pubmed: 17099194
pmcid: 2577036
Van Calster B, Van Huffel S. Integrated discrimination improvement and probability-sensitive AUC variants[J]. Stat Med, 2010, 29(2): 318-9.
pubmed: 20027623
Collins G S, Reitsma J B, Altman D G, et al. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement[J]. Ann Intern Med, 2015, 162(1): 55-63.
pubmed: 25560714
Li X, Yu W, Liang C, et al. INHBA is a prognostic predictor for patients with colon adenocarcinoma[J]. BMC Cancer, 2020, 20(1): 305.
pubmed: 32293338
pmcid: 7161248
Liang W, Zhang L, Jiang G, et al. Development and validation of a nomogram for predicting survival in patients with resected non-small-cell lung cancer[J]. J Clin Oncol, 2015, 33(8): 861-9.
pubmed: 25624438
Tian S, Li Q, Li R, et al. Development and validation of a prognostic nomogram for hypopharyngeal carcinoma[J]. Front Oncol, 2021, 11: 696952.
pubmed: 34235086
pmcid: 8255987
Fang C, Wang W, Feng X, et al. Nomogram individually predicts the overall survival of patients with gastroenteropancreatic neuroendocrine neoplasms[J]. Br J Cancer, 2017, 117(10): 1544-1550.
pubmed: 28949958
pmcid: 5680463
Zhang S, Tong Y X, Zhang X H, et al. A novel and validated nomogram to predict overall survival for gastric neuroendocrine neoplasms[J]. J Cancer, 2019, 10(24): 5944-5954.
pubmed: 31762804
pmcid: 6856574
Landry C S, Lin H Y, Phan A, et al. Resection of at-risk mesenteric lymph nodes is associated with improved survival in patients with small bowel neuroendocrine tumors[J]. World J Surg, 2013, 37(7): 1695-700.
pubmed: 23657749
Landerholm K, Zar N, Andersson R E, et al. Survival and prognostic factors in patients with small bowel carcinoid tumour[J]. Br J Surg, 2011, 98(11): 1617-24.
pubmed: 21858790
Wang Y Z, Carrasquillo J P, Mccord E, et al. Reappraisal of lymphatic mapping for midgut neuroendocrine patients undergoing cytoreductive surgery[J]. Surgery, 2014, 156(6): 1498-502; discussion 1502-3.
pubmed: 25456941
Watzka F M, Fottner C, Miederer M, et al. Surgical treatment of NEN of small bowel: a retrospective analysis[J]. World J Surg, 2016, 40(3): 749-58.
pubmed: 26822157
Massimino K P, Han E, Pommier S J, et al. Laparoscopic surgical exploration is an effective strategy for locating occult primary neuroendocrine tumors[J]. Am J Surg, 2012, 203(5): 628-631.
pubmed: 22459446
Boudreaux J P, Klimstra D S, Hassan M M, et al. The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the jejunum, ileum, appendix, and cecum[J]. Pancreas, 2010, 39(6): 753-66.
pubmed: 20664473
Cives M, Anaya D A, Soares H, et al. Analysis of postoperative recurrence in stage I-III midgut neuroendocrine tumors[J]. J Natl Cancer Inst, 2018, 110(3): 282-289.
pubmed: 29741649
Selberherr A, Niederle M B, Niederle B. Surgical treatment of small intestinal neuroendocrine tumors G1/G2[J]. Visc Med, 2017, 33(5): 340-343.
pubmed: 29177162
pmcid: 5697499
Bergestuen D S, Aabakken L, Holm K, et al. Small intestinal neuroendocrine tumors: prognostic factors and survival[J]. Scand J Gastroenterol, 2009, 44(9): 1084-91.
pubmed: 19572232
Kelly S, Aalberg J, Kim M K, et al. A predictive nomogram for small intestine neuroendocrine tumors[J]. Pancreas, 2020, 49(4): 524-528.
pubmed: 32282765
Van Den Heede K, Chidambaram S, Van Slycke S, et al. Long-term survival of metastatic small intestine neuroendocrine tumors: a meta-analysis[J]. Endocr Relat Cancer, 2022, 29(3): 163-173.
Zhao Y Y, Chen S H, Wan Q S. A prognostic nomogram for distal bile duct cancer from Surveillance, Epidemiology, and End Results (SEER) database based on the STROBE compliant[J]. Medicine (Baltimore), 2019, 98(46): e17903.
Zuo Z, Zhang G, Song P, et al. Survival nomogram for stage IB non-small-cell lung cancer patients, based on the SEER database and an external validation Cohort[J]. Ann Surg Oncol, 2021, 28(7): 3941-3950.
pubmed: 33249521