Recommendation on an updated standardization of serum magnesium reference ranges.

Humans Magnesium Reference Standards Reference Values

CLMD Chronic latent magnesium deficit Hypomagnesemia Serum magnesium Serum magnesium reference range

Journal

European journal of nutrition

ISSN: 1436-6215

Titre abrégé: Eur J Nutr

Pays: Germany

ID NLM: 100888704

Informations de publication

Date de publication:
Oct 2022

Historique:

received: 11 11 2021

accepted: 13 05 2022

pubmed: 11 6 2022

medline: 14 9 2022

entrez: 10 6 2022

Statut: ppublish

Résumé

Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members' hospitals and laboratories, presenting an urgent need for standardization. We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Serum magnesium levels designating "hypomagnesemia" differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from "normal" populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used "normal" ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To appropriately diagnose, increase awareness of, and manage magnesium status, it is critical to standardize lower reference values for serum magnesium at 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L).

Identifiants

DOI: 10.1007/s00394-022-02916-w PMID: 35689124 PMC: PMC9186275

pubmed: 35689124

doi: 10.1007/s00394-022-02916-w

pii: 10.1007/s00394-022-02916-w

pmc: PMC9186275

doi:

Substances chimiques

Magnesium I38ZP9992A

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

3697-3706

Commentaires et corrections

Type : CommentIn

Informations de copyright

Références

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